Registration Dossier
Registration Dossier
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EC number: 202-784-1 | CAS number: 99-75-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset Substance ID: 99-75-2
- Author:
- IUCLID
- Year:
- 2 000
- Bibliographic source:
- http://esis.jrc.ec.europa.eu/ with reference to Montefibre S.p.A
- Report date:
- 2000
- Reference Type:
- secondary source
- Title:
- Fragrance raw materials monographs. Methyl p-toluate
- Author:
- Opdyke DLJ
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology, Vol. 17 Suppl. 183-184
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Skin irritation test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl p-toluate
- EC Number:
- 202-784-1
- EC Name:
- Methyl p-toluate
- Cas Number:
- 99-75-2
- Molecular formula:
- C9H10O2
- IUPAC Name:
- methyl 4-methylbenzoate
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact or abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 h
- Observation period:
- no data
- Number of animals:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: no data
- Remarks on result:
- other: moderately irritating
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the test substance was moderately irritating (applikation to intact or abraded rabbit skin for 24 hours under occlusion).
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