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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Significant methodological deficiencies
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Tierexperimentelle Untersuchungen zur Toxizität des Bariumstearates
Author:
Schmidt, P. et al.
Year:
1975
Bibliographic source:
Zeitschrift für die gesamte Hygiene und ihre Grenzgebiete 21: 613 - 617.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Determination of the lethal dose of barium stearate by intraperitoneal injection in the abdominal area of rats.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: from own institute random breeding
- Weight at study initiation: 204 g (180 - 220 g)
- Housing: in groups of 10 rats
- Diet: pelletised standard feed (Sorte K) of the Staatlichen Zentralstelle für Versuchstierzucht und - versorgung Berlin
- Water (ad libitum)

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
peanut oil
Details on exposure:
Intraperitoneal injections of the test substance were given into the lower left side of the abdomen.
Doses:
8 doses (the number of doses was derived from the total number of animals divided by the number of animals used per dose; the doses were not further described)
No. of animals per sex per dose:
10 female rats
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 8 days
- Frequency of observations and weighing: the examination of the surviving animals were conducted from 8:00 to 12:00 o'clock, if not otherwise stated.
- The animals were killed through exsanguination after etherisation.
Statistics:
The lethal dose was calculated according to Litchfield and Wilcoxon (1949)*

* Reference:
Litchfiled, jr., I.T., and W.F. Wilcoxon: J. Pharmacol. exper. Therapeut. 96 (1949), 99.

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
1 850 mg/kg bw
Based on:
test mat.
95% CL:
1 600 - 2 150
Remarks on result:
other: LD50 of barium stearate was calculated 8 days after study initiation.
Sex:
female
Dose descriptor:
LD50
Effect level:
352 mg/kg bw
Based on:
element
95% CL:
304 - 400
Remarks on result:
other: LD50 of barium was calculated 8 days after study initiation.
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Conclusions:
LD50 (female rats, intraperitoneal injection): 1850 mg/kg