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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study did not meet current guideline requirements for acute inhalation.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1956
Report date:
1956

Materials and methods

Principles of method if other than guideline:
This study was conducted to investigate the potential for acute toxicity following short, high concentrations of the test substance.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(diethoxymethylsilyl)propylamine
EC Number:
221-660-8
EC Name:
3-(diethoxymethylsilyl)propylamine
Cas Number:
3179-76-8
Molecular formula:
C8H21NO2Si
IUPAC Name:
3-[diethoxy(methyl)silyl]propan-1-amine
Details on test material:
- Name of test material (as cited in study report): Gamma-aminopropylmethyldiethoxysilane
- Substance type: Cyclic siloxane
- Physical state: Liquid
- Analytical purity: No data
- Stability under test conditions: No data
- Storage condition of test material: No data

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
air
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Concentrations:
Maximum vapour concentration that could be generated at room temperature by means of a gas washing apparatus. Concentration not included in study report.
No. of animals per sex per dose:
Six males only
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Remarks on result:
other: Not determined no concentration given in the study report.

Any other information on results incl. tables

Weight gains were normal and there were no gross pathological findings.

Applicant's summary and conclusion

Interpretation of results:
other: Not possible to determine as concentration not given in report.
Conclusions:
In a non-guideline, non-GLP acute inhalation study (reliability score 4) rats survived an 8-hour exposure to the maximum concentration of a vapour of 3-(diethoxymethylsilyl)propylamine that could be generated. The concentration was not given in the study report. There were no affects on body weight gains and no gross pathological findings.