Registration Dossier
Registration Dossier
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EC number: 203-135-5 | CAS number: 103-69-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutation Research
- Author:
- Kusakabe, Hirokazu; Yamakage, Kohji; Wakuri, Shinobu; Sasaki, Kiyoshi; Nakagawa, Yuzuki; Watanabe, Mika; Hayashi, Makoto; Sofuni, Toshio; Ono, Hiroshi; Tanaka, Noriho
- Year:
- 2 002
- Bibliographic source:
- Kusakabe, Hirokazu; Yamakage, Kohji; Wakuri, Shinobu; Sasaki, Kiyoshi; Nakagawa, Yuzuki; Watanabe, Mika; Hayashi, Makoto; Sofuni, Toshio; Ono, Hiroshi; Tanaka, Noriho ; Mutation Research; vol. 517; nb. 1-2; (2002); p. 187 - 198
Materials and methods
- Type of assay:
- in vitro mammalian chromosome aberration test
Method
Species / strain
- Species / strain / cell type:
- Chinese hamster lung fibroblasts (V79)
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
Results and discussion
Test results
- Species / strain:
- Chinese hamster lung fibroblasts (V79)
- Metabolic activation:
- with and without
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Additional information on results:
- Chromosome aberation-positive with the minimum effective dose manifesting over 50 percent
cytotoxicity.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive
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