Registration Dossier
Registration Dossier
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EC number: 200-529-9 | CAS number: 62-33-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not many details available
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicity and metabolism of ethylenediaminetetraacetic, diethylenetriaminepentaacetic, and meso-2,3-diaminobutanetetraacetic acids
- Author:
- Pleskova A, Hladka A, Trnovec T
- Year:
- 1 967
- Bibliographic source:
- Bratislavske Lekarske Listy 47, 540-547
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- acute study via iv and ip injection
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium calcium edetate
- EC Number:
- 200-529-9
- EC Name:
- Sodium calcium edetate
- Cas Number:
- 62-33-9
- Molecular formula:
- C10H12CaN2O8.2Na
- IUPAC Name:
- calcium disodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: intravenous and intraperitoneal
- Vehicle:
- not specified
- Doses:
- no exact data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 544 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: intravenous injection
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 8 893 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: intraperitoneal injection
Applicant's summary and conclusion
- Conclusions:
- Intravenous administration of EDTA-CaNa2 in rabbits resulted in an LD 50 value of 5544 mg/kg bw, and intraperitoneal administration in an LD50 value of 8893 mg/kg bw.
- Executive summary:
On mice the toxicity of sodium and calcium salts of the meso-2,3 -diaminebutanetetraacetic (CaNa2 -DBTA), diethylenetriaminepentaacetic (CaNa3 -DTPA), and ethylenediaminetetraacetic (CaNa2 -EDTA) acids was determined. LD50 of CaNa2 -EDTA following i. v. injection is 5.54 g/kg bw, after i. p. injection, 8.89 g/kg bw, that of CaNa3 -DTPA after i. v. injection is 0.75 g/kg bw and of CaNa2 -DBTA after i. p. injection, 4.64 g/kg bw.
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