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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case study
Adequacy of study:
supporting study
Study period:
not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source containing minimal information. Primary source not available.

Data source

Reference
Reference Type:
secondary source
Title:
Toxicological Profile for Tin and Tin Compounds
Author:
Harper, C., Llados, F., Diamond, G. & Chappell, L.L.
Year:
2005
Bibliographic source:
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. Primary Source: Rey C. et. al. (1984) Methyltin intoxication in six men: Toxicologic and clinical aspects. Vet Hum Toxicol 26: 121-122.

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
neurotoxicity
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Case study of workers exposure.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
Mixture of half dimethyltin and half trimethyltin chloride vapour.

Method

Type of population:
occupational
Subjects:
6 workers. Male and female.
Ethical approval:
not specified
Route of exposure:
inhalation
Exposure assessment:
not specified
Details on exposure:
Maximum exposure was a total of 1.5 hours over a 3 day working period. No estimates of exposure levels were given.

Results and discussion

Any other information on results incl. tables

Six chemical workers exposed to methyltins primarily by inhalation experienced headache, tinnitus, deafness, impaired memory, disorientation, aggressiveness, psychotic and other severe neuropsychiatric behaviour, syncope and loss of consciousness as symptoms of exposure; one subject died. The two surviving workers with the highest urinary tin levels exhibited fixed neurological effects which were not resolved more than six years after exposure. The remaining three survivors returned to work, but had memory loss, which persisted for six months.

Applicant's summary and conclusion

Conclusions:
A mixture of half dimethyltin and half trimethyltin chloride vapour.
Executive summary:

Six chemical workers exposed to methyltins primarily by inhalation experienced headache, tinnitus, deafness, impaired memory, disorientation, aggressiveness, psychotic and other severe neuropsychiatric behaviour, syncope and loss of consciousness as symptoms of exposure; one subject died. The two surviving workers with the highest urinary tin levels exhibited fixed neurological effects which were not resolved more than six years after exposure. The remaining three survivors returned to work, but had memory loss, which persisted for six months.