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Physical & Chemical properties

Partition coefficient

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Description of key information

The Pow value of the test substance at neutral pH and 20°C was 3.1. It corresponds with a log Pow value of 0.49.

Key value for chemical safety assessment

Log Kow (Log Pow):
0.49
at the temperature of:
20 °C

Additional information

This study has been performed according to OECD guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method) and EU Method A. 8 (Partition Coefficient) and in accordance with GLP practices. According to the guidelines, the determination of the Powof the test substance should be performed in its non-ionised form. Therefore, the pKavalues of the test substance were calculated using the Perrin calculation method (pKalc 5.0, module in Pallas 3.0, CompuDrug International).Based on the calculations, it was decided to perform the shake flask method at neutral pH.

Pow value was determined to be 3.1 at 20°C with a neutral pH with a corresponding log Pow value of 0.49 at 20°C with a neutral pH.