Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Accepted method of estimation for risk assessment

Data source

Reference
Reference Type:
other: Estimate
Title:
Estimation of Dermal Absorption Rate for Dimethyl glutarate using U.S. EPA DERMWIN v2.01 (September 2010)
Author:
INVISTA
Year:
2011
Bibliographic source:
unpublished

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Estimated using U.S. EPA DERMWIN v2.01 (September 2010)
Principles of method if other than guideline:
The Dermal Permeability Coefficient Program (DERMWIN) estimates the dermal permeability coefficient (Kp) and the dermally absorbed dose per event (DAevent) of organic compounds.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
CAS No.: 001119-40-0
SMILES : O=C(OC)CCCC(=O)OC
CHEM : Pentanedioic acid, dimethyl ester
MOL FOR: C7 H12 O4
MOL WT : 160.17
Radiolabelling:
no

Test animals

Species:
other: Estimate
Strain:
other: Estimate

Administration / exposure

Details on study design:
Log Kow (user-entered): 0.49 (used in Kp calculations)

GENERAL Equation: log Kp = -2.72 + 0.71 log Kow - 0.0061 MW

Results and discussion

Any other information on results incl. tables

GENERAL Equation: Kp (predicted): 4.19e-004 cm/hr

Dermally Absorbed Dose per Event:

  Water Conc (mg/cm3): 26 (estimated by program)

  Event Duration (hr): 1

  DA(event): 2.77e-002 mg/cm2-event

       (tau = 0.843 hr, t* = 2.02 hr)

 

Applicant's summary and conclusion