Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

No data are available for the submission substance, 3-(triethoxysilyl)propanethiol. However, reliable test data are available for a structurally analogous substance 3-trimethoxysilylpropane-1-thiol (CAS 4420-74-0).

Short-term toxicity data for the surrogate substance indicate that aquatic invertebrates are the most susceptible trophic level. Data are available with Danio rerio (tested as Brachydanio rerio), Daphnia magna and Desmodesmus subspicatus (tested as Scendesmus subspicatus) reporting LC50 and EC50 values of 439, 6.7 and 931 mg/l for the three organisms respectively. A NOEC value of 40 mg/l was also reported in the algal study.

Data waivers based on risk characterisation ratios (RCRs) being <1, are applicable to long-term data for fish.

Thiols are more toxic to aquatic invertebrates in the short-term compared to other trophic levels. In addition, they are understood to be more toxic in the long term to aquatic invertebrates than predicted by short-term toxicity results. Therefore, it is proposed to conduct a long-term toxicity to aquatic invertebrates study (Annex IX) OECD 211:Daphnia magna reproduction test.