3-(triethoxysilyl)propanethiol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1976

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report Date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

- Name of test material (as cited in study report): Mercapto subsituted silane ester Y-9261

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals and environmental conditions:

TEST ANIMALS

- Source: Carnegie-Mellon Research Institute
- Age at study initiation: 3-4 weeks
- Weight at study initiation: 90-120 g
- Diet: ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

16, 8 and 4 ml/kg

No. of animals per sex per dose:

3 (16 ml/kg), 5 (8 ml/kg), 5 (4 ml/kg)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

6.17 mL/kg bw

Based on:

test mat.

95% CL:

ca. 4.57 - ca. 8.33

Effect levels 2

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

6 108 mg/kg bw

Remarks on result:

other: Based on specific gravity 0.99g/cm3

Mortality:

3/3 deaths in 16 ml/kg dose group, 4/5 deaths in 8 ml/kg group, 0/5 in 4 ml/kg group.

Clinical signs:

In the highest dose group (16 ml/kg) the animals were seen to be sluggish, deep breathing, with tremor-like muscular spasms and loss of coordination. The symptoms progressed to salivation and convulsions followed by the death of all three animals. Similar clinical signs were evident in the 8 ml/kg dose group, with the death of 4/5 animals. There were no deaths in the lowest dose group, but the animals appeared sluggish.

Body weight:

There were no remarkable changes in body weight.

Gross pathology:

In victims, petechial haemorrhages or congestion in the lungs; livers mottled; kidneys speckled and slightly congested; stomachs and intestines distended and liquid or gas-filled; intestines yellow. Nothing remarkable in survivors.

Other findings:

None reported.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

An acute oral LD50 value of 6.17 ml/kg (estimated to be equivalent to 6108 mg/kg bw) in rat is reported in a reliable study conducted according to a protocol equivalent to guideline.