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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
long-term toxicity to fish, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Data of test chemical
Justification for type of information:
Data for the test chemical is from collection of data
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: Refer below principle
Principles of method if other than guideline:
WoE report is prepared based on long term toxicity to fish study:
1 and 2nd
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
other: Fish
Test type:
semi-static
Water media type:
freshwater
Total exposure duration:
28 d
Reference substance (positive control):
not specified
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.134 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 1st study
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.173 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 2nd study
Validity criteria fulfilled:
not specified
Conclusions:
1. After the exposure of test chemical with fish for 28 days, NOEC was observed at 0.134 mg/l.
2. After the exposure of test chemical with fish for 28 days, NOEC was observed at 0.173 mg/l.
Thus on the basis of above available data, it can be concluded that the test chemical was toxic to fish and classified as aquatic chronic 3 as per the CLP classification criteria.
Executive summary:

Various long term studies available for the test chemical were reviewed to determine the toxic nature of test chemical on the mortality and other long term effect of fish. The studies are as mentioned below:

Based on the prediction, the long term toxicity on fish was predicted for test substance. On the basis of no effects were observed in a semi static freshwater system, the NOEC value for the test substance is estimated to be 0.134 mg/l for fish for 28 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to fish at environmentally relevant concentrations and can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria. 

Similarly in the another study based on the prediction, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a freshwater system, the NOEC value for the test substance is estimated to be 0.173 mg/l for fish for 28 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to fish at environmentally relevant concentrations and chemical was readily biodegradable in water thus on that basis it can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria. 

Thus on the basis of above available data, it can be concluded that the test chemical was toxic to fish and classified as aquatic chronic 3 as per the CLP classification criteria.

Description of key information

1. After the exposure of test chemical with fish for 28 days, NOEC was observed at 0.134 mg/l.

2. After the exposure of test chemical with fish for 28 days, NOEC was observed at 0.173 mg/l.

Thus on the basis of above available data, it can be concluded that the test chemical was toxic to fish and classified as aquatic chronic 3 as per the CLP classification criteria.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
0.134 mg/L

Additional information

Various long term studies available for the test chemical and structually and functionally similar read across chemicals were reviewed to determine the toxic nature of test chemical on the mortality and other long term effect of fish. The studies are as mentioned below:

Based on the prediction, the long term toxicity on fish was predicted for test substance. On the basis of no effects were observed in a freshwater system, the NOEC value for the test substance is estimated to be 0.134 mg/l for fish for 28 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to fish at environmentally relevant concentrations and can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria. 

Similarly in the another study based on the prediction, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a freshwater system, the NOEC value for the test substance is estimated to be 0.173 mg/l for fish for 28 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to fish at environmentally relevant concentrations and chemical was readily biodegradable in water thus on that basis it can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria. 

Thus on the basis of above available data, it can be concluded that the test chemical was toxic to fish and classified as aquatic chronic 3 as per the CLP classification criteria.