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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Data for test chemical
Justification for type of information:
Data for the test chemical is from collection of data
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: Refer below principle
Principles of method if other than guideline:
WoE report is prepared based on long term toxicity to invertebrate study:
1 and 2nd
GLP compliance:
no
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Daphnia sp.
Details on test organisms:
- Common name: Water flea
Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
21 d
Reference substance (positive control):
not specified
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.136 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
immobilisation
Remarks on result:
other: 1st study
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.17 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
immobilisation
Remarks on result:
other: 2nd study
Validity criteria fulfilled:
not specified
Conclusions:
1. On the basis of no effects observed in a freshwater system, the NOEC value for the test substance is estimated to be 0.136 mg/l for daphnia for 21 days of exposure duration.
2. On the basis of no effects observed on the freshwater daphnia, the NOEC value for the test substance is estimated to be 0.170 mg/l for daphnia for 21 days of exposure duration.
Thus based on the above data it was concluded that the chemical was toxic and as it is readily biodegradable in water tus classified as aquatic chronic 3 category as per the CLP classification criteria.
Executive summary:

Data for the long term toxicity of test chemical on the mobility and mortality of test organism daphnia were summarized and studies are as mention below:

Based on the prediction, the long term toxicity on aquatic invertebrate daphnia species was predicted for test substance. On the basis of no effects observed in a freshwater daphnia, the NOEC value for the test substance is estimated to be 0.136 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical was toxic to daphnia at environmentally relevant concentrations and chemical was readily biodegradable in water thus can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria. 

Above toxic nature of test chemical was supported by the second study. Based on the prediction, the long term toxicity on aquatic invertebrate daphnia magna was predicted for test substance. On the basis of no effects observed in a static freshwater daphnia, the NOEC value for the test substance is estimated to be 0.170 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to daphnia at environmentally relevant concentrations and chemical was readily biodegradable in water thus can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria. 

Thus based on the above data it was concluded that the chemical was toxic and as it is readily biodegradable in water tus classified as aquatic chronic 3 category as per the CLP classification criteria.

Description of key information

1. On the basis of no effects observed in a freshwater system, the NOEC value for the test substance is estimated to be 0.136 mg/l for daphnia for 21 days of exposure duration.

2. On the basis of no effects observed on the freshwater daphnia, the NOEC value for the test substance is estimated to be 0.170 mg/l for daphnia for 21 days of exposure duration.

Thus based on the above data it was concluded that the chemical was toxic and as it is readily biodegradable in water tus classified as aquatic chronic 3 category as per the CLP classification criteria.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.136 mg/L

Additional information

Data for the long term toxicity of test chemical and structually and functionally similar read across chemicals on the mobility and mortality of test organism daphnia were summarized and studies are as mention below:

Based on the prediction, the long term toxicity on aquatic invertebrate daphnia species was predicted for test substance. On the basis of no effects observed in a freshwater daphnia, the NOEC value for the test substance is estimated to be 0.136 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical was toxic to daphnia at environmentally relevant concentrations and chemical was readily biodegradable in water thus can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria. 

Above toxic nature of test chemical was supported by the second study. Based on the prediction, the long term toxicity on aquatic invertebrate daphnia magna was predicted for test substance. On the basis of no effects observed in a freshwater daphnia, the NOEC value for the test substance is estimated to be 0.170 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to daphnia at environmentally relevant concentrations and chemical was readily biodegradable in water thus can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria. 

Thus based on the above data it was concluded that the chemical was toxic and as it is readily biodegradable in water thus chemical classified as aquatic chronic 3 category as per the CLP classification criteria.