Registration Dossier
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EC number: 907-706-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Data for test chemical
- Justification for type of information:
- Data for the test chemical is from collection of data
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- WoE report is prepared based on long term toxicity to invertebrate study:
1 and 2nd - GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia sp.
- Details on test organisms:
- - Common name: Water flea
- Test type:
- flow-through
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.136 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- immobilisation
- Remarks on result:
- other: 1st study
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.17 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- immobilisation
- Remarks on result:
- other: 2nd study
- Validity criteria fulfilled:
- not specified
- Conclusions:
- 1. On the basis of no effects observed in a freshwater system, the NOEC value for the test substance is estimated to be 0.136 mg/l for daphnia for 21 days of exposure duration.
2. On the basis of no effects observed on the freshwater daphnia, the NOEC value for the test substance is estimated to be 0.170 mg/l for daphnia for 21 days of exposure duration.
Thus based on the above data it was concluded that the chemical was toxic and as it is readily biodegradable in water tus classified as aquatic chronic 3 category as per the CLP classification criteria. - Executive summary:
Data for the long term toxicity of test chemical on the mobility and mortality of test organism daphnia were summarized and studies are as mention below:
Based on the prediction, the long term toxicity on aquatic invertebrate daphnia species was predicted for test substance. On the basis of no effects observed in a freshwater daphnia, the NOEC value for the test substance is estimated to be 0.136 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical was toxic to daphnia at environmentally relevant concentrations and chemical was readily biodegradable in water thus can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria.
Above toxic nature of test chemical was supported by the second study. Based on the prediction, the long term toxicity on aquatic invertebrate daphnia magna was predicted for test substance. On the basis of no effects observed in a static freshwater daphnia, the NOEC value for the test substance is estimated to be 0.170 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to daphnia at environmentally relevant concentrations and chemical was readily biodegradable in water thus can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria.
Thus based on the above data it was concluded that the chemical was toxic and as it is readily biodegradable in water tus classified as aquatic chronic 3 category as per the CLP classification criteria.
Reference
Description of key information
1. On the basis of no effects observed in a freshwater system, the NOEC value for the test substance is estimated to be 0.136 mg/l for daphnia for 21 days of exposure duration.
2. On the basis of no effects observed on the freshwater daphnia, the NOEC value for the test substance is estimated to be 0.170 mg/l for daphnia for 21 days of exposure duration.
Thus based on the above data it was concluded that the chemical was toxic and as it is readily biodegradable in water tus classified as aquatic chronic 3 category as per the CLP classification criteria.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.136 mg/L
Additional information
Data for the long term toxicity of test chemical and structually and functionally similar read across chemicals on the mobility and mortality of test organism daphnia were summarized and studies are as mention below:
Based on the prediction, the long term toxicity on aquatic invertebrate daphnia species was predicted for test substance. On the basis of no effects observed in a freshwater daphnia, the NOEC value for the test substance is estimated to be 0.136 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical was toxic to daphnia at environmentally relevant concentrations and chemical was readily biodegradable in water thus can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria.
Above toxic nature of test chemical was supported by the second study. Based on the prediction, the long term toxicity on aquatic invertebrate daphnia magna was predicted for test substance. On the basis of no effects observed in a freshwater daphnia, the NOEC value for the test substance is estimated to be 0.170 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to daphnia at environmentally relevant concentrations and chemical was readily biodegradable in water thus can be considered to be classified as aquatic chronic 3 category as per the CLP classification criteria.
Thus based on the above data it was concluded that the chemical was toxic and as it is readily biodegradable in water thus chemical classified as aquatic chronic 3 category as per the CLP classification criteria.
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