Registration Dossier
Registration Dossier
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EC number: 204-648-7 | CAS number: 123-75-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of Pyrrolidine to aquatic algae was assessed according to
OECD guideline No. 201 and GLP principles. Nominal exposure
concentrations were the following:
Range-finding test: 0.1, 1.0, 10 and 100 mg/L;
Final test: 1.0, 3.2, 10, 32 and 100 mg/L
The EC50 for growth rate reduction (ERC50: 0 -72h) was 39 mg/L and the
EC10 (ERC10: 0 -72h) was 10 mg/L. The EC50 for yield inhibition (EYC50:
0-72h) was 16 mg/L and the EC10 for yield inhibition (EYC10: 0-72h) was
4.2 mg/L. All criteria for acceptability of the test were met according
to OECD guideline No. 201 and the test is categorized as reliable
without restrictions.
The toxicity of Pyrrolidine to marine algae (Skeletonema costatum) was
assessed according to ISO 1025. The ErC50 resultet in 3.1 mg/L after 72h.
The test was categorized as reliable with restrictions.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 39 mg/L
- EC50 for marine water algae:
- 3.1 mg/L
- EC10 or NOEC for freshwater algae:
- 10 mg/L
Additional information
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