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Short-term toxicity to fish

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Description of key information

96 h LC50 ca. 215 mg active acid/L (r-a) Salmo gairdneri (new name: Oncorhynchus mykiss) (read-across, reliabilty 1)
96 h LC50 6435 mg active acid/L (r-a) Cyprinodon variegatus (read-across, reliabilty 1)

Key value for chemical safety assessment

Additional information

DTPMP-xNH4 will dissociate when it is released into aqueous environments to yield DTPMP and ammonia.

The assessment of short-term toxicity of the substance to fish and the resulting hazard classification are therefore, in the absence of test data for the substance, based on treating the substance as a preparation. Test data do not indicate that DTPMP acid is toxic to fish following short-term exposure. However, the un-ionised ammonia moiety is however known to be toxic to aquatic organisms and concentration limits, as stipulated in the Annex I (DSD)/Annex VI (CLP) entry for ammonia.

DTPMP and ammonia will also be treated separately for the purposes of deriving PNECs for the aquatic compartment. A PNECaquatic for ammonia has already been derived by the UK Environment Agency for the purpose of setting an Environmental Quality Standard (EQS) under Annex VIII of the Water Framework Directive (WFD). The relevant data are presented in section 7.6 of the CSR. This PNEC is also considered to be adequate for the purpose of risk characterisation of ammonia present in DTPMP-xNH4. A PNEC for DTPMP will be determined using test data for the substance.

Freshwater

No data on short term toxicity of DTPMP-xK salts, CAS 84852-49-3, on short term toxicity to freshwater fish are available, however since the data is related to active acid content and it is possible to freely read-across from DTPMP acid (CAS 15827-60-8) and sodium salt (CAS 22042 -96 -2) to the potassium salt and the lowest EC50 is represented by data on the acid, this has been read-across.

A reliable 96 h LC50 value of ca. 215 mg/L (as active acid) has been determined for the effects of DTPMP acid on the mortality of the freshwater fish Salmo gairdneri (new name: Oncorhynchus mykiss).

The results of tests conducted on DTPMP and its salts are directly comparable, because the substance will fully dissociate in solution and the ionisation state will depend only on the pH of the test medium. The counterion is not considered to contribute to effects in fish. At environmentally-relevant pH values, DTPMP will be ionised typically 6-8 times, and will form stable complexes with metal ions.

Here, the value of 215 mg active acid/L may be directly read-across.

 

Marine

No data on short term toxicity of DTPMP-xK salts, CAS 84852-49-2, to marine fish are available. However, a reliable 96 h LC50 value of 6435 mg active acid/l has been determined for the effects of DTPMP acid (CAS 15827-60-8) towards the mortality of the marine fish Cyprinodon variegatus.

The results of tests conducted on DTPMP and its salts are directly comparable, because the substance will fully dissociate in solution and the ionisation state will depend only on the pH of the test medium. The counterion is not considered to contribute to effects in fish. At environmentally-relevant pH values, DTPMP will be ionised typically 6-8 times, and will form stable complexes with metal ions.

Here, the value of 6435 mg equivalent active acid/L may be directly read-across.