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Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The key infromation is read across from DTPMP acid (CAS 15827 -60 -8) in the absence of available data for the sensitisation endpoint of DTPMP-xK.

In in vivo toxicity studies the local pH and ionic conditions within the stomach, GI tract etc. dominate the speciation of the phosphonate, irrespective of the form originally dosed. At a defined pH, a salt will behave no differently to the parent acid, at identical concentration of the particular speciated form present, and will be fully dissociatedto yield DTPMP acid and ammonium .Hence some properties for a salt (in contact with water or in aqueous media) can be directly read across (with suitable mass correction) to the parent acid and vice versa (see CSR for mass correction values). In the present context the effect of the alkaline metal counter-ion (sodium/ammonium) will not be significant and has been extensively discussed in the public literature. In biological systems and the environment, polyvalent metal ions will be present, and the phosphonate ions show very strong affinity to them.


Migrated from Short description of key information:
There are no data on the skin sensitising potential of ammonium salts of DTPMP. Therefore data on DTPMP (acid) have been read across.

In a guinea pig maximisation study conducted before OECD TG 406 and GLP (reliability score 2) DTPMP was not sensitising to the skin of guinea-pigs (Unilever 1979).

Justification for classification or non-classification

The available data suggest that there is no need to classify ammonium salts of DTPMP for sensitising potential.