Allylamine

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1960

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Limited information supplied

Data source

Reference

Reference Type:

publication

Title:

The Toxicity of Allylamines

Author:

Hine, CH et al

Year:

1960

Bibliographic source:

Archives of Environmental Health, Volume 1, Pages 343-352

Materials and methods

Type of study / information:

Volunteers were exposed to concentrations of 2.5, 5, 10 and 14 ppm for sensory threshhold determination

Endpoint addressed:

eye irritation

other: olfactory cognition... (see attached file)

Principles of method if other than guideline:

Whole body exposure to allylamine for up to 5 minutes, assessing by use of an arbitrary scale

GLP compliance:

no

Remarks:

Old study

Test material

Test material information

Constituent 1

Reference substance name:

Allylamine

EC Number:

203-463-9

EC Name:

Allylamine

Cas Number:

107-11-9

Molecular formula:

C3H7N

IUPAC Name:

prop-2-en-1-amine

Test material form:

other: liquid

Details on test material:

Molecular weight: 57.09
Boiling point: 52.9 deg C
Melting point: -88.2 deg C
Flash point, tag open cup: -20 deg F
Specific Gravity, 20/4 C: 0.7627
Solubility in water, 20 deg C, %W: complete
pH of 0.1M aqueous solution: 11.2
ppm in 1 mg/mL: 429

Method

Ethical approval:

not specified

Details on study design:

Whole body exposure to vapour over 5 minute periods

Exposure assessment:

measured

Details on exposure:

Volunteers exposed in whole body chambers to concentrations of 2.5, 5, 10 and 14 ppm allylamine

Results and discussion

Results:

Odour was unpleasant and recognised by all subjects at 2.5 ppm. Eye and nose irritation, pulmonary discomfort and CNS effects (slight headache, nausea) were also noted by some at this level.

At 14 ppm irritation of eyes, nose and throat, and pulmonary discomfort were considered intolerable, and exposure was terminated at once.

There was no icrease in CNS effects with increasing concentration, apparently.

Applicant's summary and conclusion

Conclusions:

In humans, allylamine is easily detected at 2.5 ppm, and is intolerable at 14 ppm.

Executive summary:

Volunteers exposed in whole body chambers to concentrations of 2.5, 5 and 10 ppm allylamine, and briefly to 14 ppm.

Odour was unpleasant and recognised by all subjects at 2.5 ppm. Eye and nose irritation, pulmonary discomfort and CNS effects (slight headache, nausea) were also noted by some at this level. At 14 ppm irritation of eyes, nose and throat, and pulmonary discomfort were considered intolerable, and exposure was terminated at once. There was no icrease in CNS effects with increasing concentration, apparently.