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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Old study, not to GLP, but similar to current guidelines

Data source

Reference
Reference Type:
publication
Title:
The Toxicity of Allylamines
Author:
Hine, CH et al
Year:
1960
Bibliographic source:
Archives of Environmental Health, Volume 1, Pages 343-352

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
only males tested
GLP compliance:
no
Remarks:
Old study
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
Molecular weight: 57.09
Boiling point: 52.9 deg C
Melting point: -88.2 deg C
Flash point, tag open cup: -20 deg F
Specific Gravity, 20/4 C: 0.7627
Solubility in water, 20 deg C, %W: complete
pH of 0.1M aqueous solution: 11.2
ppm in 1 mg/mL: 429

Test animals

Species:
rat
Strain:
Long-Evans
Sex:
male
Details on test animals and environmental conditions:
Animals weighed 120-160 g

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: whole body
- Exposure chamber volume: 19.5L
- Method of holding animals in test chamber: not stated
- Source and rate of air:7.0-9.5 L/min (source not stated)
- Method of conditioning air: not stated
- System of generating vapour: air passing over evaporator
- Treatment of exhaust air: not stated
- Temperature, humidity, pressure in air chamber: not stated

TEST ATMOSPHERE
- Brief description of analytical method used: by theoretical calculation

Analytical verification of test atmosphere concentrations:
no
Remarks:
but concentrations calculated
Duration of exposure:
8 h
Concentrations:
89, 133, 200 and 300 ppm
No. of animals per sex per dose:
5 males
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes, where possible
Statistics:
LC50 calculated by method of Weil, 1952.

Results and discussion

Preliminary study:
Not applicable
Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
177 ppm
95% CL:
151 - 209
Exp. duration:
8 h
Mortality:
89 ppm: 0/5
133 ppm: 0/5
200 ppm: 4/5 (8-24 hours)
300 ppm: 5/5 (8-24 hours)
Clinical signs:
other: At all concentrations, allylamine was irritating to the eye and upper respiratory tract as indicated by face-washing motions. Lacrimation and nasal discharge followed at higher levels. A few rats showed severe air hunger, with gasping, at the highest co
Gross pathology:
The stomachs of rats that died were greatly distended with air, and the lungs contained fluid. Those surviving as long as 3 hours had haemorrhage into the alveolar spaces and acute pulmonary oedema. No gross or microscopic abnormalities were observbed among survivors.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category II
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The 8 hour LC50 of allylamine was 177 (151-209) ppm
Executive summary:

Mortality of male rats after 8 hours exposure to allylamine was:

89 ppm: 0/5

133 ppm: 0/5

200 ppm: 4/5 (8 -24 hours)

300 ppm: 5/5 (8-24 hours)