Allylamine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

Old study, not to GLP, but similar to current guidelines

Data source

Reference

Reference Type:

publication

Title:

The Toxicity of Allylamines

Author:

Hine, CH et al

Year:

1960

Bibliographic source:

Archives of Environmental Health, Volume 1, Pages 343-352

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

only males tested

GLP compliance:

no

Remarks:

Old study

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Allylamine

EC Number:

203-463-9

EC Name:

Allylamine

Cas Number:

107-11-9

Molecular formula:

C3H7N

IUPAC Name:

prop-2-en-1-amine

Test material form:

other: liquid

Details on test material:

Molecular weight: 57.09
Boiling point: 52.9 deg C
Melting point: -88.2 deg C
Flash point, tag open cup: -20 deg F
Specific Gravity, 20/4 C: 0.7627
Solubility in water, 20 deg C, %W: complete
pH of 0.1M aqueous solution: 11.2
ppm in 1 mg/mL: 429

Test animals

Species:

rat

Strain:

Long-Evans

Sex:

male

Details on test animals or test system and environmental conditions:

Animals weighed 120-160 g

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: whole body
- Exposure chamber volume: 19.5L
- Method of holding animals in test chamber: not stated
- Source and rate of air:7.0-9.5 L/min (source not stated)
- Method of conditioning air: not stated
- System of generating vapour: air passing over evaporator
- Treatment of exhaust air: not stated
- Temperature, humidity, pressure in air chamber: not stated

TEST ATMOSPHERE
- Brief description of analytical method used: by theoretical calculation

Analytical verification of test atmosphere concentrations:

no

Remarks:

but concentrations calculated

Duration of exposure:

8 h

Concentrations:

89, 133, 200 and 300 ppm

No. of animals per sex per dose:

5 males

Control animals:

no

Details on study design:

- Duration of observation period following administration: 10 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes, where possible

Statistics:

LC50 calculated by method of Weil, 1952.

Results and discussion

Preliminary study:

Not applicable

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

177 ppm

95% CL:

151 - 209

Exp. duration:

8 h

Mortality:

89 ppm: 0/5
133 ppm: 0/5
200 ppm: 4/5 (8-24 hours)
300 ppm: 5/5 (8-24 hours)

Clinical signs:

other: At all concentrations, allylamine was irritating to the eye and upper respiratory tract as indicated by face-washing motions. Lacrimation and nasal discharge followed at higher levels. A few rats showed severe air hunger, with gasping, at the highest co

Gross pathology:

The stomachs of rats that died were greatly distended with air, and the lungs contained fluid. Those surviving as long as 3 hours had haemorrhage into the alveolar spaces and acute pulmonary oedema. No gross or microscopic abnormalities were observbed among survivors.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category II

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The 8 hour LC50 of allylamine was 177 (151-209) ppm

Executive summary:

Mortality of male rats after 8 hours exposure to allylamine was:

89 ppm: 0/5

133 ppm: 0/5

200 ppm: 4/5 (8 -24 hours)

300 ppm: 5/5 (8-24 hours)