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EC number: 203-463-9 | CAS number: 107-11-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Old study, not to GLP, but similar to current guidelines
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicity of Allylamines
- Author:
- Hine, CH et al
- Year:
- 1 960
- Bibliographic source:
- Archives of Environmental Health, Volume 1, Pages 343-352
Materials and methods
- Principles of method if other than guideline:
- Following OECD401 guideline, but using intraperitoneal dosing
- GLP compliance:
- no
- Remarks:
- Old study
- Limit test:
- no
Test material
- Reference substance name:
- Allylamine
- EC Number:
- 203-463-9
- EC Name:
- Allylamine
- Cas Number:
- 107-11-9
- Molecular formula:
- C3H7N
- IUPAC Name:
- prop-2-en-1-amine
- Test material form:
- other: liquid
- Details on test material:
- Molecular weight: 57.09
Boiling point: 52.9 deg C
Melting point: -88.2 deg C
Flash point, tag open cup: -20 deg F
Specific Gravity, 20/4 C: 0.7627
Solubility in water, 20 deg C, %W: complete
pH of 0.1M aqueous solution: 11.2
ppm in 1 mg/mL: 429
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Princeton
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Animals weighed 13-22 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- VEHICLE
- Concentration in vehicle: 1%
- Amount of vehicle (if gavage): Varies with dose level - Doses:
- 20, 40, 80 and 160 mg/kg
- No. of animals per sex per dose:
- 5 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes, where possible - Statistics:
- LD50 calculated by method of Weil, 1952.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 49 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 37 - 65
- Mortality:
- 20 mg/kg: 0/5
40 mg/kg: 1/5 (4 days)
80 mg/kg: 5/5 (3-4 hours)
160 mg/kg: 5/5 (1-2 hours) - Clinical signs:
- Decreased activity, but hyper-reaction to touch was observed after about one hour
- Gross pathology:
- Mice that died had congested lungs, livers and spleens, grossly, but no histologic change.
Applicant's summary and conclusion
- Conclusions:
- LD50 was 49 mg/kg (37-65)
- Executive summary:
Mortality in male mice was:
20 mg/kg: 0/5
40 mg/kg: 1/5 (4 days)
80 mg/kg: 5/5 (3-4 hours)
160 mg/kg: 5/5 (1-2 hours)
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