Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-463-9 | CAS number: 107-11-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Old study, not to GLP, but similar to current guidelines
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicity of Allylamines
- Author:
- Hine, CH et al
- Year:
- 1 960
- Bibliographic source:
- Archives of Environmental Health, Volume 1, Pages 343-352
Materials and methods
- Principles of method if other than guideline:
- Following OECD401 guideline, but using intraperitoneal dosing
- GLP compliance:
- no
- Remarks:
- Old study
- Limit test:
- no
Test material
- Reference substance name:
- Allylamine
- EC Number:
- 203-463-9
- EC Name:
- Allylamine
- Cas Number:
- 107-11-9
- Molecular formula:
- C3H7N
- IUPAC Name:
- prop-2-en-1-amine
- Test material form:
- other: liquid
- Details on test material:
- Molecular weight: 57.09
Boiling point: 52.9 deg C
Melting point: -88.2 deg C
Flash point, tag open cup: -20 deg F
Specific Gravity, 20/4 C: 0.7627
Solubility in water, 20 deg C, %W: complete
pH of 0.1M aqueous solution: 11.2
ppm in 1 mg/mL: 429
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Princeton
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Animals weighed 13-22 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- VEHICLE
- Concentration in vehicle: 1%
- Amount of vehicle (if gavage): Varies with dose level - Doses:
- 20, 40, 80 and 160 mg/kg
- No. of animals per sex per dose:
- 5 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes, where possible - Statistics:
- LD50 calculated by method of Weil, 1952.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 49 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 37 - 65
- Mortality:
- 20 mg/kg: 0/5
40 mg/kg: 1/5 (4 days)
80 mg/kg: 5/5 (3-4 hours)
160 mg/kg: 5/5 (1-2 hours) - Clinical signs:
- Decreased activity, but hyper-reaction to touch was observed after about one hour
- Gross pathology:
- Mice that died had congested lungs, livers and spleens, grossly, but no histologic change.
Applicant's summary and conclusion
- Conclusions:
- LD50 was 49 mg/kg (37-65)
- Executive summary:
Mortality in male mice was:
20 mg/kg: 0/5
40 mg/kg: 1/5 (4 days)
80 mg/kg: 5/5 (3-4 hours)
160 mg/kg: 5/5 (1-2 hours)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
