Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Toxicological assessment of flavouring esters
Author:
Grundschober, F.
Year:
1977
Bibliographic source:
Toxicology, 8(1977) 387-390

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Hydrolysis of flavouring esters including citronellyl acetate by pancreatin.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Citronellyl acetate
EC Number:
205-775-0
EC Name:
Citronellyl acetate
Cas Number:
150-84-5
Molecular formula:
C12H22O2
IUPAC Name:
3,7-dimethyloct-6-en-1-yl acetate
Test material form:
not specified
Details on test material:
no details provided
Radiolabelling:
no

Test animals

Species:
other: not applicable
Strain:
other: not applicable

Administration / exposure

Route of administration:
other: not applicable
Duration and frequency of treatment / exposure:
not applicable
Doses / concentrations
Remarks:
Doses / Concentrations:
not applicable
No. of animals per sex per dose / concentration:
not applicable
Control animals:
other: not applicable

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
ester and alcohol

Any other information on results incl. tables

After 2 hours of incubation with pancreatin, the hydrolysis of citronellyl 
acetate was complete (100 %).
No further data given.

Applicant's summary and conclusion