Cyclohexanone, 4-methoxy-

Endpoint summary

Description of key information

Oral (Rat, GLP, OECD TG 423): LD50 > 2000 mg/kg

Dermal (Rat, GLP, OECD TG 402): LD50 > 2000 mg/kg

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

April - May 2006

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Version / remarks:

2001

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

yes

Species:

rat

Strain:

Wistar

Sex:

female

Route of administration:

oral: gavage

Vehicle:

corn oil

Doses:

2000 mg/kg bw.

No. of animals per sex per dose:

2 x 3 animals

Control animals:

no

Details on study design:

16-24h fasting pre-dosing, feeding 2-4h after oral gavage

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

no mortalities

Clinical signs:

other:

The clinical signs were decreased motility and uncoordinated gait.

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

the test item is of low acute oral toxicity

Executive summary:

A dose of 2000 mg/kg body weight was tolerated by female rats without mortalities, effects on weight gain and gross pathological findings.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

> 2 000 mg/kg bw

Quality of whole database:

Klimisch 1

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March - May 2006

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

1987

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

fixed dose procedure

Limit test:

yes

Species:

rat

Strain:

Wistar

Sex:

male/female

Type of coverage:

semiocclusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hours

Doses:

2000 mg/kg bw.

No. of animals per sex per dose:

5 male and 5 female

Control animals:

no

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

no mortalities occured

Clinical signs:

other:

The following local clinical sign was observed: partial reddening of the test area.

There were no toxicological effects on body weight or body weight development in males. In one female a decrease in body weight gain was observed in the first week.

The necropsies performed at the end of the study revealed no particular findings.

Interpretation of results:

GHS criteria not met

Conclusions:

the test item is of low acute dermal toxicity

Executive summary:

Groups of 5 male and 5 female Wistar rats received a single dermal dose of 2000 mg/kg body weight of the test compound applied semiocclusively for 24 hours.

Based on the present investigations, 4-Methoxycyclohexanone is to be regarded to have the following LD50 values:
LD50 rat, male : > 2000 mg/kg body weight; rat, female : > 2000 mg/kg body weight

So it is regarded as very low toxic after dermal application.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

> 2 000 mg/kg bw

Quality of whole database:

Klimisch 1

Justification for classification or non-classification

Based on the study results a classification according to Regulation (EC) No. 1272/2008 (CLP) is not required.