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EC number: 480-410-8 | CAS number: 13482-23-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March - May 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1987
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 480-410-8
- EC Name:
- -
- Cas Number:
- 13482-23-0
- Molecular formula:
- Hill formula: C7H12O2 CAS formula: C7H12O2
- IUPAC Name:
- 4-methoxycyclohexan-1-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw.
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortalities occured
- Clinical signs:
- other:
Any other information on results incl. tables
The following local clinical sign was observed: partial reddening of the test area.
There were no toxicological effects on body weight or body weight development in males. In one female a decrease in body weight gain was observed in the first week.
The necropsies performed at the end of the study revealed no particular findings.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- the test item is of low acute dermal toxicity
- Executive summary:
Groups of 5 male and 5 female Wistar rats received a single dermal dose of 2000 mg/kg body weight of the test compound applied semiocclusively for 24 hours.
Based on the present investigations, 4-Methoxycyclohexanone is to be regarded to have the following LD50 values:
LD50 rat, male : > 2000 mg/kg body weight; rat, female : > 2000 mg/kg body weightSo it is regarded as very low toxic after dermal application.
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