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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Jan. 2012-June 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: OECD 111
GLP compliance:
yes
Medium:
acetone
Solubility:
10 g/L
Temp.:
20 °C
Remarks on result:
other: 5 mg/ml in acetone
Medium:
other: hexane
Solubility:
25 mg/L
Temp.:
20 °C
Remarks on result:
other: for calibration standards; maximum concentration was not investigated.
Test substance stable:
yes
Conclusions:
Octenyl succinic anhydride is soluble in acetone and hexane at 20 degrees C.
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
other: OECD 471
Principles of method if other than guideline:
Stability in organic solvents was investigated during a bacterial reverse mutation assay according to OECD guideline 471.
GLP compliance:
yes
Medium:
DMSO
Temp.:
37 °C
Remarks on result:
other: no data on concentration in DMSO
Test substance stable:
yes
Conclusions:
Octenyl succinic anhydride (OSA) was found to be soluble in dimethyl sulphoxide (DMSO) in a bacterial mutagenicity protocol.
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Jan. 2012-Sept. 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
other: OECD 107
Principles of method if other than guideline:
Stability in organic solvents was investigated during the process of an n-octanol:water partition coefficient study on this substance.
GLP compliance:
yes
Medium:
acetone
Solubility:
10 g/L
Temp.:
22 °C
Medium:
other: hexane
Solubility:
> 25 mg/L
Temp.:
22 °C
Remarks on result:
other: 25 mg/L was the highest level tested (as a calibration standard), and maximum solubility may be higher.
Test substance stable:
yes
Conclusions:
Octenyl succinic anhydride (OSA) was determined to be soluble and stable in organic solvents (n-octanol, hexane, acetone) as part of a study on n-octanol:water partition coefficient and substance analytical verification.

Description of key information

Soluble in acetone, hexane and DMSO.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
10 g/L

Additional information

Octenyl succinic anhydride is soluble in acetone, hexane and dimethyl sulphoxide at room temperature.