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EC number: 629-679-7 | CAS number: 42482-06-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Flash point
- Auto flammability
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- Explosiveness
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- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
- Biodegradation
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar 2012 to May 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
- Reference substance name:
- 3-(oct-2-en-1-yl)dihydrofuran-2,5-dione
- EC Number:
- 629-679-7
- Cas Number:
- 42482-06-4
- Molecular formula:
- C12H18O3
- IUPAC Name:
- 3-(oct-2-en-1-yl)dihydrofuran-2,5-dione
- Test material form:
- other: Liquid
- Details on test material:
- Octenyl Succinic Anhydride
Lot#: 44514821
Gulf Bayport Chemicals
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Harlan Labs, Inc.
- Age at study initiation: 8 to 10 weeks
- Weight at study initiation: 161 - 192 grams
- Fasting period before study: Overnight
- Housing:Single. In suspended stainless steel caging with mesh floors
- Diet (e.g. ad libitum): ad libitum Harlan Teklad Global 16% protein Rodent diet #2016.
- Water (e.g. ad libitum): Filtered tap water ad libitum
- Acclimation period: 6-15 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23 degrees C
- Humidity (%): 26-69
- Air changes (per hr): 14-15 per hour
- Photoperiod (hrs dark / hrs light): 12/ 12
IN-LIFE DATES: From: To: Feb 20 - Mar 27, 2012
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Individual doses were calculated based on initial body weights, taking into account the density of the test substance as determined by PSL.
- Doses:
- Initially, a single animal received a limit dose of 2,000 mg/kg. Due to mortality of this animal, a main test was conducted. For the main test, the substance was administered in sequence to the animals, starting at 175 mg/Kg, progressing to 550 mg/Kg to a final dose of 2000 mg/Kg. The decision to proceed with the next animal was based on the survival of the previous animal following dosing.
- No. of animals per sex per dose:
- 3 per dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observed once daily. Weighing on day 1, 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights: Particular attention was paid to tremors, convulsions, salivation, diarrhea and coma. - Statistics:
- The Acute Oral toxicity ( Guideline 425) statistical program (Westat, version 1.0, May 2001) was used for all data analysis including: dose progression selections, stopping criteria determinations and/ or LD 50 and confidence limit calculations.
Results and discussion
- Preliminary study:
- One animal given the limit dose of 2000 mg/ Kg did not survive.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 098 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 550 - < 2 000
- Mortality:
- Three animals died after receiving 2000 mg/kg. Three animals survived after receiving 550 mg/kg.
- Clinical signs:
- other: All animals given 2000 mg/kg died within one day of test substance administration.
- Gross pathology:
- Toxic signs included: irregular respiration, hyperactivity, abnormal posture, piloerection and/ or reduced fecal volume. Gross necropsy of the decedents revealed discoloration of the lungs and/or stomach and intestines, a mottled liver and/ or distention of the intestines and/or stomach.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Octenyl succinic anhydride (OSA) was tested in an up and down acute toxicity OECD 425 protocol in female rats. The LD50 was determined to be 1098 mg/kg bw. This is associated with CLP category IV for classification according to regulation EC No. 1272/ 2008.
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