Bis(2,3-epoxypropyl) terephthalate

Endpoint summary

Additional information

In a first study the substance was tested according to OECD 203. The 96-h EC50 was determined to be 8.8 mg/L; calculated from the geometric average concentrations of the EC0 (5.6 mg/L) and the 71% mortality observed at 10 mg/L. Since the test was performed with a mixture containing 60 to 100% of the substance and assuming that the effects observed are entirely due to the substance, by dividing the experimental LC50 for fish by 1.6 (corresponding to 60% of the substance) the resulting LC50 is around 5.5 mg/L. The substance is therefore considered to be moderately toxic to fish.

In a second study the acute toxicity of the test item to rainbow trout (Oncorhynchus mykiss) was determined in a 96-hour semi static test based on the OECD Guideline No 203 and EU Method C.1. The procedure to prepare a filtrate of a dispersion, which stirred only for 1 hour, was chosen due to the instability of the test item. The concentration of the hydrolysis products should be as low as possible in the freshly prepared test media. However, using this approach the concentration of the test item was highly variable. Based on the test results the 96-hour test with bis(2,3-epoxypropyl)terephthalate on rainbow trouts (Oncorhynchus mykiss), the LC₀was determined in the second run and is 0.638 mg test item/L based on mean measured concentrations. The LC₁₀₀was determined in the first run and is 1.57 mg test item/L also based on mean measured concentrations. Since the test item concentrations were not reproducible during the test and as a large range of variability was observed (between 0.22 and 2.7 mg test item/L), no reliable LC₅₀could be determined

The substance was not acutely toxic to Daphnia magna when tested according to OECD 202 in a semi-static test. The 48-h NOEC was determined to be 1.69 mg/L which was the highest achievable test item concentration to be dissolved in the test water.

In another study, the product Araldite PT 910 was tested for acute toxicity to Daphnia in a static test according to OECD 202 guideline.Since the test was performed with a mixture containing 60 to 100% of the substance and assuming that the effects observed were entirely due to the substance, by dividing the experimental EC50 for daphnia by 1.6 (corresponding to 60% of the substance) the resultant EC50 was found to be around 50 mg/L. The substance is therefore considered to be moderately toxic to Daphnia.

The substance was reported to have moderate toxicity to the green algae Pseudokirchnerella subcapitata, with a 72-h EL50 value for growth rate of greater than 2.94 mg/L (nominal), and for biomass of 1.13 mg/L (nominal) in an OECD guideline study (Test No. 201).

The substance was reported to have very low toxicity to microorganisms derived from activated sludge, with a 3-h IC50 value for growth inhibition of 2536.5 mg/L in an OECD guideline study (Test No. 209).