Registration Dossier
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EC number: 230-565-0 | CAS number: 7195-44-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Two studies were performed to determine the acute toxicity of bis(2,3-epoxypropyl)terephthalate to aquatic invertebrates.
The first study was performed with a mixture containing at least 60% of the test substance in a static 48-hour immobilisation test and a second study was performed on bis(2,3-epoxypropyl)terephthalate in a Semi-Static 48-hour Immobilisation Test according to OECD 202 and the Commission Regulation (EC) No 440/2008, C.2.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 50 mg/L
Additional information
In a first study TKK 30041 Araldite PT 910 was tested for acute toxicity to Daphnia in a static test according to OECD 202 guideline. Since the test was performed with a mixture containing 60 to 100% of the substance and assuming that the effects observed are entirely due to the substance, by dividing the experimental EC50 for daphnia by 1.6 (corresponding to 60% of the substance) the resultant EC50 is around 50 mg/L. The substance is therefore considered to be moderately toxic to Daphnia.
In a second study, the acute Toxicity of bis(2,3-epoxypropyl)terephthalatetoDaphnia magna was determined in a semi static 48-hour immobilisation test. The test was conducted in accordance with OECD Guideline 202 and theCommission Regulation (EC) No 440/2008. This study encompassed 6 treatment groups (5 test item concentrations: A Filtrate of nominal 100 mg test item/L and sequential dilutions of 1:2, 1:4, 1:8 and 1:16; corresponding to the geometric mean measured concentrationsof 1.69, 0.851, 0.474, 0.228 and 0.117mg test item/L and a control) each containing 20 individuals. The immobility of the Daphnia was determined by visual observation after 24 and 48 hours of test duration.The samples collected at test start and after 48 hours were analysed via HPLC method.After 24 and 48 hours in the control and all test item concentrations no immobilisation of the test animals was observed. The 48-hour NOEC was determined to be 1.69 mg test item/L. The 48-hour LOEC was determined to be > 1.69 mg test item/L The 48-hour EC50 value was calculated to be > 1.69 mg test item/L (all values based on geometric mean measured concentrations).
No EC50 value could be determined in the semi-static test as no immobility was observed at the highest value tested. The EC50 value obtained in the static test with the mixture containing at least 60% of bis(2,3-epoxypropyl)terephthalate and extrapolated to the worst case (all effects due to the substance) was taken into consideration for the key value for risk assessment.
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