Bis(2,3-epoxypropyl) terephthalate

Toxicity to microorganisms

Description of key information

Toxicity of bis(2,3-epoxypropyl) terephthalate to Activated Sludge in a Respiration Inhibition Test

Key value for chemical safety assessment

EC50 for microorganisms:

2 536.5 mg/L

EC10 or NOEC for microorganisms:

18.6 mg/L

Additional information

In comparison to the inoculum controls the respiration rate of the activated sludge was slightly inhibited by 11.9% at the lowest nominal test concentration of 10 mg/L. At the next higher concentrations of nominal 32 and 100 mg/L the inhibition was 14.3%. The respiration rate of the activated sludge was moderately inhibited by 28.6% at 320 mg/L. At a nominal concentration of 1000 mg/L, the respiration rate was inhibited by 42.9% at a plateau. Concentrations exceeding 1000 mg/L nominal were not tested.

Based on measured inhibition rates, the 3-hour EC₁₀, EC₂₀and EC₅₀and their 95% confidence limits were determined.

The results are listed below:

      Parameter         EC₁₀           EC₂₀           EC₅₀

   Value [mg/L]           18.6           100.5         2536.5

   lower 95%-cl             0.1            11.7           817.1

   upper 95%-cl           64.0           238.1     180059.8