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EC number: 248-470-8 | CAS number: 27458-93-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No measured data are available for the long-term toxicity to invertebrates of the registration substance. The assessment of effects is based on available data for its constituents. The available evidence indicates that only the tetradecan-1-ol constituent has long-term effects in invertebrates. No further testing is necessary.
Key value for chemical safety assessment
Additional information
A 21-d NOEC of 0.98 mg/L has been determined for the effects of octadecan-1-ol on reproduction rate and mortality of D. magna. The result is much higher than the limit of solubility of the test substance and should be treated with caution; the test substance did not appear to be toxic at the limit of solubility.
For tetradecan-1-ol, a reliable 21 d NOECrepro value of 1.6 µg/L has been identified for the effect of the test substance on the cumulative number of offspring of D. magna using an adapted semi-static test regime to minimise losses of the substance in test media between renewals.
For hexadecan-1-ol, no measured data are available for this endpoint. Therefore this endpoint has been calculated based on a validated reliable QSAR method to determine a NOEL value of >0.01 mg/L, i.e. non-toxic at the limit of solubility.
A 21-d NOEC(reproduction) value of 20.6 µg a.i./L has been determined for the effects of octadecanol, branched (single branch at the 2-position) on the number of reproductive young produced per day (D. magna). While this test is largely reliable, the interpretation is made very difficult by a number of uncertainties. The stock was prepared at a concentration which would have significantly exceeded the limit of solubility of the substance, and use of a proportional diluter without adequate equilibration time could have delivered undissolved material to test vessels, even at the nominal concentration levels that would have been below the limit of solubilty. The use of a flow-through test system with such a rapidly degradable substance may mean that microbial growth contributed to effects seen. It is not possible to be certain whether the analytical measurements made were of dissolved or undissolved test substance. The NOEC determined is significantly out of line compared to the clear trend of NOECs seen for alcohols with carbon number up to C14 (Schäfers et al., 2009). For all of these reasons, the study is disregarded in the present assessment.
For the purpose of risk characterisation, PNECs have been set for each constituent (by carbon number) individually. Branching is considered not to be significant.
For the purpose of hazard assessment, the contribution of each constituent to the toxicity of the registration substance has been considered. The substance contains C14 (linear only, 1% w/w), also linear and branched C16 (8.5% w/w in total), C18 (>80%) and C20. C14 has long-term effects in invertebrates.
Using the NOEC (rather than EC10) based on mean measured concs in fresh and old media, and setting the constituents C16 C18 and C20 as non-toxic at the limit of solubility: A NOELR of 0.17 mg/l whole substance is estimated using this method.
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