Registration Dossier
Registration Dossier
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EC number: 231-124-5 | CAS number: 7440-15-5
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, follows a standard operating procedure, available as an unpublished report, reliable without restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Standard Operating Procedure (SOP) prepared by Eurometaux on November 2010
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Rhenium
- EC Number:
- 231-124-5
- EC Name:
- Rhenium
- Cas Number:
- 7440-15-5
- Molecular formula:
- Re
- IUPAC Name:
- rhenium
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Particle size distribution information and specific surface area information was taken from Fraunhofer IKTS report 4187_4205 of 12.11.2012
Sample: Rhenium powder
Metal: Re
% w/w: >99.9
d50, um: 94.86
d90, um: 252.856
BET, m2/g: 0.394
Constituent 1
Results and discussion
Any other information on results incl. tables
The results from the bio-elution study with rhenium powder are presented in following Table:
PSD (µm) |
BET (m2/g) |
Metal release |
||||
% release |
Absolute release (µg/g) |
Surface area release(µg/m2) |
||||
Rhenium powder |
D50: 94.86 D90: 252.86 |
0.394 |
||||
Gastric |
2 h |
0.23 |
2287.4 |
5805.6 |
||
Dermal |
24 h |
0.61 |
6092.4 |
15462.9 |
||
168 h |
1.4 |
13882.5 |
35234.8 |
|||
Applicant's summary and conclusion
- Conclusions:
- The results of the bio-elution study confirm that under the conditions of the test, only relatively small concentrations of rhenium ions are released.
- Executive summary:
The results of the bio-elution study with gastric fluid show 0.23% release of rhenium in after 2 hours. The results from the dermal study show 0.61% release after 24 hours and 1.4% release after 168 hours.
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