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EC number: 939-420-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Reliability 2 studies for skin and eye irritation
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1948-06
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Apply 0.01mL of undiluted sample to an area of the clipped belly of an albino rabbit and observe the area after 24-hours, recording necrosis, edema,erythema or congestion of capillaries.
- GLP compliance:
- no
- Remarks:
- Conducted prior to the advent of GLP.
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No additional data available.
- Type of coverage:
- open
- Preparation of test site:
- other: Clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.01mL of undiluted sample.
- Duration of treatment / exposure:
- Single treatment.
- Observation period:
- Observed after 24-hours
- Number of animals:
- 5 rabbits
- Details on study design:
- Apply 0.01mL of undiulted sample to an area of the clipped belly of an albino rabbit and observe the area after 24-hours, recording necrosis, edema,erythema or congestion of capillaries.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- other: assessment was for only 24 hours - no irritation was reported
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- other: assessment was for only 24 hours - no irritation was reported
- Remarks:
- no indication of irritation
- Irritant / corrosive response data:
- Diisobutyl carbinol produced minimum detectable capillary injection on 1 of 5 rabbits.
- Other effects:
- No additional effects noted.
- Interpretation of results:
- not irritating
- Conclusions:
- The compound is non irritating to the rabbit skin.
- Executive summary:
Apply 0.01mL of undiulted sample to an area of the clipped belly of an albino rabbit and observe the area after 24-hours, recording necrosis, edema, erythema or congestion of capillaries. Diisobutyl carbinol produced minimum detectable capillary injection on 1 of 5 rabbits.
Reference
No additional information or table available.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Principles of method if other than guideline:
- Measured volumes of undiluted fluid chemicals are placed on the center of the cornea of an ablino rabbit which has just previously been shown to have uninjured eyes, and 24-hours later observe the eye for gross evidence of injury and for corneal necrosis revealed by fluorescein stain. The
volumes used are 0.001, 0.005, 0.02. 0.1 and 0.5 mL. - GLP compliance:
- no
- Remarks:
- Conducted prior to the advent of GLP.
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or tissues and environmental conditions:
- No additional details on animals and environmental conditions.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- An excess of undiluted material.
- Duration of treatment / exposure:
- 24-hour.
- Observation period (in vivo):
- After 24-hours.
- Number of animals or in vitro replicates:
- 5 eyes.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24 h
- Remarks on result:
- not measured/tested
- Remarks:
- Only minor damage to the cornea was reported - observed after 24 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24 h
- Remarks on result:
- not measured/tested
- Remarks:
- Only minor damage to the cornea was reported - observed after 24 hours
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24 h
- Remarks on result:
- not measured/tested
- Remarks:
- Only minor damage to the cornea was reported - observed after 24 hours
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 2
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- other: Only minor damage to the cornea was reported - observed after 24 hours
- Irritant / corrosive response data:
- Minor damage to the cornea resulted from the instillation of an excess of undiluted material. This result regulates the compound to Grade 2 in our
10-grade rating series comparable in activity to "Carbitol". - Interpretation of results:
- not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Minor damage to the cornea resulted from the instillation of an excess of undiluted material. This result relegates the compound to Grade 2 in our
10-grade rating series comparable in activity to "Carbitol". Carbitol (Diethylene Glycol ethyl ether) is not classified as an eye irritant, therefore DIBC is not considered to be irritating - Executive summary:
Exposure to an excess of undiluted diisobutyl carbinol results in minor damage to the cornea. this result relegates the compound to Grade 2 in our 10 -grade rating series comparable in sensivity to "Carbitol".
Reference
No additional information on results or tables are available.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
In a reliability 2 study, DIBC was not considered to be irritating to the skin.
Eye irritation
In a reliability 2 study rabbit eyes were exposed to an excess of DIBC. This resulted in minor damage to the cornea placing it into category 2 out of 10, considered to be mildly irritating.
Justification for classification or non-classification
DIBC is not considered to be irriating to the skin.
The data available on eye irritation are insufficient on their own to assign a classification according to CLP (and GHS). However, this substance was considered to be a grade 2 eye irritant (on a scale of 1 -10). This grade of 2 for irritation is also assigned to other materials such as Diethylene Glycol ethyl ether. This substance is not classified as irritating to the eyes, therefore by analogy, DIBC is not considered to be an eye irritant according to CLP (and GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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