Registration Dossier

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to the analogue approach justification provided in section 13.
Reason / purpose:
read-across source
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Conclusions:
A 96-h LC50 >100 mg/l in Danio rerio was obtained in a guideline test and in accordance with GLP. The result is taken to be reliable.

Description of key information

A 96-hr LC50 of > 100 mg/l , Brachydanio rerio

Key value for chemical safety assessment

Additional information

A 96 hour LC50value of > 50mg/l and NOEC of ≥ 50 mg/l have been determined for the effects of the test substance on mortality of Oncorhynchus mykiss (OECD Guideline 203 Fish Acute Toxicity Test, Smithers Viscient, 2012). The corresponding mean measured concentration of the substance in the treated test medium over the course of the test could not be determinated. No effects could be detected up to the highest tested concentration but the maximum nominal concentration used (50 mg/l) was well below the predicted solubility of the substance (13000 mg/l) and so does not provide an accurate representation of the likely toxicity of the substance. Therefore it was considered appropriate to read across from the structurally analogous substance, N-ethyl-3-trimethoxysilyl-2-methylpropanamine (CAS No. 227085-51-0). A limit test was conducted at a test concentration of 100 mg/l (OECD Guideline 203 Fish Acute Toxicity Test, RCC Ltd, 2001).

No effects were observed at this concentration to Zebra Fish (Brachydanio rerio). As the substance is subject to rapid hydrolysis, it is therefore likely that the test organisms were also exposed to hydrolysis products retained in the test media.