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Toxicity to microorganisms

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Description of key information

Toxicity to microorganisms: EC50 > 1000 mg/l

Key value for chemical safety assessment

Additional information

There are no microorganism toxicity data available for N-[3-(trimethoxysilyl)propyl]butylamine (CAS No. 31024-56-3), therefore good quality data for the analogue substance, N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS No. 3068-78-8) have been read across. Both substances share comparable silanol hydrolysis products, N-[3-(trihydroxysilyl)propyl]butylamine N-[3-(trihydroxysilyl)propylcyclohexylamine]. It is therefore considered valid to read-across the results for N-[3-(trimethoxysilyl)propylcyclohexylamine] to fill the data gap for the registered substance. The other hydrolysis product is methanol, which does not have adverse effects on microorganisms (OECD, 2004).

Both substances are within a wider analogue group than the analogue group discussed in Section 1.4. Substances within this wider analogue group, in general, exhibit no evidence of significant toxicity to microorganisms.

This wider analogue group for the toxicity to microorganisms endpoint consists of a number of sub-classes of substances. However, read-across is carried out between substances with the same sub-class in most cases.

Table7.1.6 presents microorganism toxicity data available for substances within the sub-class (III-8) of substances having amino group(s) in side chain after any very rapid hydrolysis has been accounted for. Both N-[3-(trimethoxysilyl)propyl]butylamine (CAS No. 031024-56-3) and N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS No. 3068-78-8) are members of this sub-class.

Table 7.1.6. Microorganism toxicity data available for substances within the relevant sub-class (III-8) of chemicals

CAS

Name

Result: E(I)C50(mg/l)

Result: NOEC (or EC10/ EC20) (mg/l)

Guideline Number

Test method

Species

Duration

Reliability

027445-54-1

Cyclohexanamine,N-[(diethoxymethylsilyl)methyl]-

624.2 mg/l    (EC20 240.2 mg/l)

 

OECD 209

ASRI

 

3hr - but stirred 24hr

1a

003068-78-8

N-[3-(trimethoxysilyl)propylcyclohexylamine]

>1000

EC20 = 203 mg/l

OECD 209

ASRI

 

3 hr

1a

157923-74-5

2,2-dimethyl-4-(trimethoxysilyl)butylamine

>1000

EC15 869. 17.5% inhibition at 1000 mg/l.

OECD 209

ASRI

 

3 hr

1a

227085-51-0

N-ethyl-3-trimethoxysilyl-2-methylpropanamine

>1000

 

OECD 209

ASRI

 

3 hr

1a

000919-30-2

3-aminopropyltriethoxysilane

43 mg/l

EC10 13 mg/l

Huls AG method

oxygen consumption

P. putida

5.75 hr

2c

082985-35-1

Bis(trimethoxysilylpropyl)amine

estimated value, approximately 1000

220

OECD 209

ASRI

 

3 hr

1a

001760-24-3

N-(3-(trimethoxysilyl)propyl)ethylenediamine

67 mg/l

EC10 25 mg/l

DIN 38 412, Part 8 (Pseudomonascell multiplication inhibition test)

growth inhibition test

P. putida

16 hr

1c

[N,N-Bis(trimethylsilyl)aminopropyl]methyldiethoxysilane

>100

 

OECD 209

ASRI

 

3 hr

1a

None

reaction mix (reaction mass of 6 benzylated amine silanes)

569

130; EC20 172

OECD 209; EC C.11

ASRI

 

3 hr

1a



Additional information is given in a supporting report (PFA, 2013l) attached in Section 13 of the IUCLID 5 dossier

The influence of the test item N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS No. 3068-78-8) were determined in a reliable study conducted according to OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test) and GLP (Ibacon, 1998). An EC50of > 1000 mg/l was determinated.