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EC number: 250-437-8 | CAS number: 31024-56-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No studies are available. Based on molecular structure, molecular weight, water solubility, and octanol-water partition coefficient it can be expected that the submission substance is unlikely to be absorbed via the oral and the inhalation routes. However, due to its skin sensitising properties, dermal uptake of the submission substance is likely. Hydrolysis is expected to occur rapidly, and toxicity data via the oral route indicate that the silanol containing degradation product is absorbed via the gastro intestinal tract. However, hydrolysis after dermal and inhalation exposure is not expected and therefore, absorption of the silanol -containing hydrolysis product is considered negligible. Based on the high water solubility of the parent substance and its hydrolysis product, distribution in the body and a fast excretion via the renal route can be expected. The bioaccumulation potential is expected to be low.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
There were no studies available, in which the toxicokinetic properties of registered substance were investigated.
N-[3-(trimethoxysilyl)propyl]butylamine (molecular weight of 235.4 g/mol) is a liquid, which is very soluble in water (QSAR calculated water solubility: 13 000 mg/l at 20°C. The log Kow is 2.2 at 20°C. Since the target substance is an alkoxysilane, it will hydrolyse with a half-life of approximately 2.2 hours at 20-25°C and pH 7 under formation of three equivalents methanol and the respective silanetriol. Acid environment is hereby known to catalyse this abiotic and enzyme-independent reaction and enhance the reaction rate, further increased by the body temperature of approximately 37 °C present in mammals. The hydrolysis product 3-(N-butylamino)propylsilanetriol is even more water soluble (QSAR calculated water solubility: 1 000 000 mg/l at 20°C. The log Kow is -0.9 at 20°C, indicating that fast excretion of the hydrolysis product via the renal route is expected and a general accumulation is unlikely.
Absorption
Oral: In an acute oral toxicity study, male rats were administered the target substance by gavage. The LD50 reported was 12 825 mg/kg bw; signs of toxicity observed were salivation, diarrhoea, unsteady gait, and sluggishness. Due to the defence reactions of the organism (salivation and diarrhoea), it is assumed that only very little of the test material was absorbed through the gastro intestinal tract. However, clinical signs such as unsteady gait and sluggishness indicate systemic availability. Since the target substance is known to underlie a fast hydrolysis, it can be assumed that the effects observed were contributed to the hydrolysis product rather than the parent substance. The hydrolysis product is assumed to be rapidly excreted via the renal route. Hence, only minor bioavailability of N-[3-(trimethoxysilyl)propyl]butylamine after oral administration is indicated.
Dermal: An acute dermal toxicity study with rabbits reveals strong skin damaging effects of the test material at the doses applied. The dermal LD50 reported was 15 200 mg/kg bw, and clinical signs were limited to local effects. However, gross pathology revealed discolouration of lungs, kidneys, spleens, and stomach, indicating systemic availability of the test material. It can be assumed that the potential to cross the skin is based on the skin irritating properties of the submission substance. Hydrolysis is considered to be of minor importance due to the low presence of water on the skin surface. In conclusion, dermal uptake of N-[3-(trimethoxysilyl)propyl]butylamine in humans is considered possible and has to be taken into account for hazard assessment.
Inhalation: N-[3-(trimethoxysilyl)propyl]butylamine has a low vapour pressure of 0.76 Pa at 25°C. Therefore, inhalation of the vaporised target substance is quite unlikely. Nevertheless, an acute inhalation toxicity study in rats was carried out, using a test atmosphere containing substantially saturated vapour of the test item. Following 6 hours of exposure no deaths occurred, and no signs of toxicity were observed. Moreover, gross pathology revealed no remarkable findings. Thus, a low hazard potential of the substance via the inhalative route can be estimated. Hydrolysis of the target substance is considered of minor importance due to the quite long half-live of the parent substance at the physiological pH in the respiratory tract.
Metabolism
No studies are available determining the metabolism of N-[3-(trimethoxysilyl)propyl]butylamine. Nevertheless, metabolism of the target substance is considered negligible, since abiotic and enzyme independent hydrolysis is the prominent degradation reaction, leading to the highly water soluble products methanol and 3-(N-butylamino)propylsilanetriol. It cannot be excluded, that further oxidation of the aliphatic group under formation of hydroxyl groups takes place, but this is considered to be insignificant and would only enhance renal excretion.
Excretion
N-[3-(trimethoxysilyl)propyl]butylamine is known to undergo hydrolysis with a half-life ofapproximately 2.2 hours at 20°C and pH 7. The hydrolysis products named above are far more water soluble than the parent chemical and have a molecular weight lower than 500 g/mol. Therefore, they are expected to be excreted predominantly via the renal route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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