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EC number: 250-437-8 | CAS number: 31024-56-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- (only limited information on test procedure and test material identity are given, and no test material purity is stated in the study report)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N-[3-(trimethoxysilyl)propyl]butylamine
- EC Number:
- 250-437-8
- EC Name:
- N-[3-(trimethoxysilyl)propyl]butylamine
- Cas Number:
- 31024-56-3
- Molecular formula:
- C10H25NO3Si
- IUPAC Name:
- butyl[3-(trimethoxysilyl)propyl]amine
- Details on test material:
- - Name of test material (as cited in study report): Silane 44-42 (organofunctional), Dynasylan 1189
- Physical state: yellow liquid
- Lot/batch No.: 09989
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 3-5 months
- Fasting period before study: none
- Diet: appropriate diet ad libitum (not further specified)
- Water: ad libitum (not further specified)
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: impervious sheeting
REMOVAL OF TEST SUBSTANCE
- Washing (if done): excess fluid was removed to prevent ingestion (not further specified)
- Time after start of exposure: 24 h - Duration of exposure:
- 24 h
- Doses:
- 2, 4, 8, and 16 mL/kg bw, equivalent to 1900, 3800, 7600, and 15200 mg/kg bw (calculated based on a density of 0.95 g/cm³)
- No. of animals per sex per dose:
- 4 animals (not further specified)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, skin irritation - Statistics:
- The LD50 along with the 95% confidence limits was calculated by the moving average method based on a 14 day observation period.
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 15 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 187.5 - <= 193 800
- Remarks on result:
- other: (equivalent to 16.0 ml/kg bw (95% CL 1.25 -204 ml/kg bw); calculated based on a density of 0.95 g/cm³)
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 1 900 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: (equivalent to 2.0 ml/kg bw; calculated based on a density of 0.95 g/cm³)
- Mortality:
- - 16 ml/kg bw: 2/4 (both deaths occured on day 3)
- 8 ml/kg bw: 1/4 (animal died on day 11 post-dosing); repeated for confirmatory purpose: deaths 2/4 (animals died on days 2 and 3)
- 4 ml/kg bw: 1/4 (animal died on day 2 post-dosing)
- 2 ml/kg bw: 0/4 - Clinical signs:
- other: - 16 ml/kg bw: Erythema, oedema, necrosis, ecchymosis, fissuring, desquamation at 14 days; Prostrate at 1 day - 8 ml/kg bw: Erythema, oedema, ecchymosis, scabs at 14 days; repeated for confirmatory purpose: Oedema, necrosis at 24 h, scabs on survivors at
- Gross pathology:
- In victims, the lungs were red, the livers mottled bright red and tan, the kidneys were found to be mottled tan and red, the spleens appeared dark, the stomacs were injected or opaque.
In survivors, nothing remarkable was observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008
- Conclusions:
- The test item was tested for acute dermal toxicity according to a test protocol that is comparable to the appropriate OECD 402 test guideline, but without GLP compliance. The test material was occlusively administered to 4 rabbits each dose group. The LD50 was determined to be 15200 mg/kg bw. The predominant clinical signs detected were signs of irritation/corrosion, such as erythema, oedema, and necrosis. No deaths occured at 1900 mg/kg bw, but still signs of skin irritation were noted. Based on this data, classification for acute dermal toxicity according to Regulation (EC) No. 1272/2008 is not warranted.
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