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EC number: 479-100-5 | CAS number: 577705-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 25 - April 9, 1993
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- -
- EC Number:
- 479-100-5
- EC Name:
- -
- Cas Number:
- 577705-90-9
- Molecular formula:
- C38H36F6O2NP
- IUPAC Name:
- benzyl(diethylamino)diphenylphosphanium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]benzen-1-olate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Batch: 14334/56
Purity: 95%
Storage conditions: at room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Number and sex:
5 males + 5 female/group
Body weight:
Males: 225-250 g; Females: 200- 225 g
Age:
7 - 9 weeks
Acclimition:
5 days before the start of the test. Animals were observed daily to ascertain their fitness for the study.
Housing:
individual caging in air-conditioned rooms. Temperature: 22°C+/-2; Relative humidity: 55%+/-10; Air changes: about 20/hour filtered on HEPA 99.97%; Light: 12 hour cycle
Administration / exposure
- Type of coverage:
- occlusive
- Details on dermal exposure:
- Administration route: epidermal
Reason for selection of administration route: possible accidental exposure for humans
Administration frequency: single
Observation period: 14 days after the administration
Preparation of animals skin: approximately 24 hours before the test, for was clipped from the dorsal and ventral area of the trunk of the test animals. Care was taken to avoid abrading the skin which could alter its permeability. An area of about 6x5cm of the body dorsal surface was cleared for the application of the test article. This area corresponding to about 10% of the total body surface.
Administration of the test article: by uniform application onto the cleared area. The treated area was covered with a porous gauze deressing fixed to the skin with hypoallergenic non irritating tape. The test side was further covered in a suitable manner in order to ensure that the animals could not ingest the test substance. At the end of the exposure period the residual test substance was wiped off. - Duration of exposure:
- 24 hours
- Doses:
- one group of 5rat/sex administered a single dose of 2000 mg/kg (limit dose).
- No. of animals per sex per dose:
- 5 males + 5 female/group
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died during the observation period.
- Clinical signs:
- other: No general clinical signs were noticed. Erythema and crusts of the skin were observed at the application site of some rats starting from day 2- 3 and lasting up to days 4 - 7 of the study.
- Gross pathology:
- Animals killed at the end of the observation period
No changes were observed in the animals killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The test article Addotto GM 102 E/BAF 1/1, when administered by dermal route to rat, under the conditions adopted in this experiment, did not cause mortality at the limit dose of 2000 mg/kg.
The LD50 by dermal route is higher than 2000 mg/kg.
Local reversible irritation changes were the only signs observed.
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