Registration Dossier
Registration Dossier
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EC number: 214-711-0 | CAS number: 1189-08-8
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
- Principles of method if other than guideline:
- The physicochemical parameters of MW, Log P and saturated aqueous solubility have been used in the evaluation of 56 methacrylate compounds. An output of predicted steady-state flux was calculated using the principles defined in the Potts and Guy prediction model. (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663- 669)
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-methyltrimethylene dimethacrylate
- EC Number:
- 214-711-0
- EC Name:
- 1-methyltrimethylene dimethacrylate
- Cas Number:
- 1189-08-8
- Molecular formula:
- C12H18O4
- IUPAC Name:
- 4-[(2-methylprop-2-enoyl)oxy]butan-2-yl 2-methylprop-2-enoate
- Test material form:
- liquid
Constituent 1
Test animals
- Details on test animals or test system and environmental conditions:
- not applicable; in silico modelling
Administration / exposure
- Type of coverage:
- other: not applicable; in silico modelling
- No. of animals per group:
- not applicable; in silico modelling
Results and discussion
- Absorption in different matrices:
- predicted flux 2.895 μg/cm²/h; the relative dermal absorption is low
Any other information on results incl. tables
Based on a molecular weight of 226.27 g/mol and ag Kow of 3.1, the predicted flux of 1,3 -BDDMA is 2.895 μg/cm²/h; the relative dermal absorption is low.
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption of 1,3-BDDMA is predicted to be low; the predicted flux is 2.895 μg/cm²/h.
- Executive summary:
The dermal absorption (steady-state flux) of 1,3 -BDDMA has been estimated by calculation using the principles defined in the Potts and Guy prediction model.
Based on a molecular weight of 226.27 g/mol and ag Kow of 3.1, the predicted flux of 1,3 -BDDMA is 2.895 μg/cm²/h; the relative dermal absorption is low.
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