Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-113-5 | CAS number: 103-45-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Insufficient methods or results details. Study completed prior to introduction of formal test guidelines or GLP principles. The report is a synopsis of results rather than a full study report and does not contain all the information normally provided in a GLP compliant report.
Data source
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Maximisation test completed in 20 human volunteers. The methods were standard for the repeat insult patch test.
- GLP compliance:
- no
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- Twenty-five adult healthy male volunteers were allocated to the study but 5 did not complete the study.
- Clinical history:
- 25 human volunteers started and 20 finished the study.
- Controls:
- No data
- Route of administration:
- dermal
- Details on study design:
- The human patch test was conducted using closed epicutaneous test methods in accordance with the Maximisation Test (J.I.D Vol. 5; 1968) of Kligman
epicutaneous, occlusive covering
Patch test used the vehicle, petrolatum, as the vehicle control.
Results and discussion
- Results of examinations:
- No information for positive controls
48 and 72 hour human patch test response - test group - concentration of test substance 10% in petrolatum: 0/20 positive responders
Any other information on results incl. tables
Following maximised exposure to twenty human volunteers, none of the subjects showed any evidence of a sensitisation response.
It was concluded that the allergenic potential for the fragrance substance is very low.
Applicant's summary and conclusion
- Conclusions:
- The allergenic potential of phenyl ethyl acetate is concluded to be very low following no positive responders in a maximisation test with twenty human volunteers.
- Executive summary:
Twenty human volunteers completed a maximisation test for allergenicity potential in which phenyl ethyl acetate was applied five times to the forearm at 10% in petrolatum in the induction phase, followed by challenge application to the dorsum again at 10% in petrolatum.
No reactions indicative of an allergic contact dermatitis were recorded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.