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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
No information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Insufficient methods or results details. Study completed prior to introduction of formal test guidelines or GLP principles. The report is a synopsis of results rather than a full study report and does not contain all the information normally provided in a GLP compliant report.

Data source

Materials and methods

Type of sensitisation studied:
Study type:
study with volunteers
Test guideline
no guideline followed
Principles of method if other than guideline:
Maximisation test completed in 20 human volunteers. The methods were standard for the repeat insult patch test.
GLP compliance:


Type of population:
Ethical approval:
not specified
Twenty-five adult healthy male volunteers were allocated to the study but 5 did not complete the study.
Clinical history:
25 human volunteers started and 20 finished the study.
No data
Route of administration:
Details on study design:
The human patch test was conducted using closed epicutaneous test methods in accordance with the Maximisation Test (J.I.D Vol. 5; 1968) of Kligman
epicutaneous, occlusive covering
Patch test used the vehicle, petrolatum, as the vehicle control.

Results and discussion

Results of examinations:
No information for positive controls

48 and 72 hour human patch test response - test group - concentration of test substance 10% in petrolatum: 0/20 positive responders

Any other information on results incl. tables

Following maximised exposure to twenty human volunteers, none of the subjects showed any evidence of a sensitisation response.

It was concluded that the allergenic potential for the fragrance substance is very low.

Applicant's summary and conclusion

The allergenic potential of phenyl ethyl acetate is concluded to be very low following no positive responders in a maximisation test with twenty human volunteers.
Executive summary:

Twenty human volunteers completed a maximisation test for allergenicity potential in which phenyl ethyl acetate was applied five times to the forearm at 10% in petrolatum in the induction phase, followed by challenge application to the dorsum again at 10% in petrolatum.

No reactions indicative of an allergic contact dermatitis were recorded.