Registration Dossier
Registration Dossier
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EC number: 203-113-5 | CAS number: 103-45-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Two studies are avaialble and report low acute oral toxicity; studies report limited methodology but are sufficient for the purposes of hazard identification and classification
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 766 mg/m³ air
- Quality of whole database:
- Guideline-comparable study for a read-across substance
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 6 210 mg/kg bw
- Quality of whole database:
- Study uses high dose levels but is adequate for the purposes of classification
Additional information
Studies of acute oral toxicity contain limited methodological detail but are sufficient for the purposes of hazard identification and classification. Moreno (1973) reports an acute oral LD50 in the rat of 5000 mg/kg bw (50% mortality at the limit dose). Rumyantsev et al (1987) report an acute oral LD50 of 5200 mg/kg bw.
In an acute inhalation toxicity study performed with the read-across substance benzyl acetate, Jackson (1997) reports no mortality at the saturated vapour concentration of 0.766 mg/L.
The acute dermal LD50 of phenyl ethyl acetate is reported to be 6210 mg/kg bw in the rabbit (Fogelman, 1971).
Justification for selection of acute toxicity – oral endpoint
Study reports a lower LD50 value
Justification for selection of acute toxicity – inhalation endpoint
Only one study available for this endpoint
Justification for selection of acute toxicity – dermal endpoint
Only one study available for this endpoint
Justification for classification or non-classification
The results of the acute toxicity studies indicate low hazard by all routes of exposure and do not trigger the classification of phenylethyl acetate according to the CLP Regulation.
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