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Administrative data

Link to relevant study record(s)

Description of key information

A toxicokinetic study with oral administration to rats revealed, that ASC Plus is resorbed readily into the body and excreted rapidly via urine as unchanged substance. 24 h after the administration serum levels were below  the limit of quantitation. Therefore no bioaccumulation potential in the body exists.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

An oral dosage of 1600 mg ASC plus/kg bw. was administered to male and female Wistar rats by stomach tube in 10 ml water/kg bw. Blood, serum, urine and feces were analyzed 3, 6, 12 and 24 hours after administration. Additionally examples of urine and feces were taken 168 hours after administration and 3, 6, 12, 24 and 168 h after an oral administration of 800 mg ASC plus/kg bw. The most relevant data are the results of the serum analysis.

The serum levels of ASC plus showed a maximum 3 h after administration. Within 24 hours these levels fall beneath the limit of quantitation.

The concentrations of ASC plus in the feces were relatively low.

The urine concentrations of ASC plus showed that relevant amounts of the test article are excreted via urine as unchanged substance.

From the present data one can assume that ASC plus is resorped readily after oral administration. Relevant amounts of an oral dosage are excreted unchanged via urine.