Registration Dossier
Registration Dossier
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EC number: 203-781-8 | CAS number: 110-59-8
Endpoint summary
Administrative data
Description of key information
The skin and eye irritation was tested on rabbits in non-GLP studies. Alll tests were perrformed either in accordance with or following the corresponding DOT- and/or EU-/OECD-test guidelines.
- Skin irritation study (Wallace, 1976): not irritant
- Skin & Eye irritation study (Guillot, 1983): not irritant
The results of the study of 1983 (Guillot) were identified as key values for the the chemical safety assessment.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The test of 1983 (Guillot) was performed according to OECD- and EU-testing guidelines, therefore it was identified as key study. The second test (Wallace, 1976) was conducted following a comparable test design, before the corresponding test guidelines were available, hence it was identified as supporting study. Both tests were not performed in accordance with GLP, therefore they were considered to have Klimisch 2.
Justification for classification or non-classification
Based on results obtained, and the CLP classification criteria, Valeronitrile is not classified for skin and eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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