Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
No information
Author:
Benigni, R
Year:
2013
Bibliographic source:
OECD Toolbox v3.1

Materials and methods

Test guideline
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
Version / remarks:
Ames test
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
1-fluoro-4-nitrobenzene
EC Number:
206-502-8
EC Name:
1-fluoro-4-nitrobenzene
Cas Number:
350-46-9
Molecular formula:
C6H4FNO2
IUPAC Name:
1-fluoro-4-nitrobenzene

Method

Species / strain
Species / strain / cell type:
S. typhimurium, other: all types
Metabolic activation:
with and without
Metabolic activation system:
S9

Results and discussion

Test results
Species / strain:
S. typhimurium, other: all types
Metabolic activation:
with and without
Genotoxicity:
negative
Remarks:
with 76.1 % certainty
Cytotoxicity / choice of top concentrations:
not determined

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with 76.1 % certainty

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