Registration Dossier
Registration Dossier
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EC number: 269-047-4 | CAS number: 68186-85-6 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77377.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Peer reviewed authority database (Peer review was conducted by a Japanese toxicological expert group at March 5, 2001. However, detailed information were not available). Furthermore test results were taken for the OECD SIDS Intital assessment report for C.I. Pigment Yellow 53.
Data source
Referenceopen allclose all
- Reference Type:
- other: Peer reviewed database
- Title:
- Unnamed
- Year:
- 2 002
- Reference Type:
- other: OECD Substance initial assessment report (SIAR)
- Title:
- SIDS Initial Assessment Report For SIAM 15 (Oct. 2002)
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- OECD SIDS Initial Assessment Report, C.I. Pigment Yellow 53, CAS No. 8007-18-9
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- C.I. Pigment Yellow 53
- IUPAC Name:
- C.I. Pigment Yellow 53
- Reference substance name:
- Antimony nickel titanium oxide yellow
- EC Number:
- 232-353-3
- EC Name:
- Antimony nickel titanium oxide yellow
- Cas Number:
- 8007-18-9
- IUPAC Name:
- 8007-18-9
- Details on test material:
- - Purity: 100%
- Lot/batch No.: 4879
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Crj; CD(SD) IGS
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: aqueous suspension in 1 % sodium carboxymethyl cellulose - Doses:
- 0, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations : at least once daily
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortalities were observed.
- Clinical signs:
- other: No clinical signs of toxicity were observed. The feces were yellow within one day after administration.
- Gross pathology:
- No gross internal lesions were observed during necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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