Registration Dossier

Toxicological information

Carcinogenicity

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Description of key information

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Although the reliability of the studies on methyl methacrylate is limited due to deviations to current carcinogenicity test guidelines (e.g., histopathologic examination was performed on a limited number of organs), they revealed no increase of neoplastic lesions after long-term exposure to methyl methacrylate therefore it is considered that methyl methacrylate has no carcinogenic potential.

Available data are limited on zinc compounds. Zinc deficiency or supplementation may influence carcinogenesis, since promoting and inhibiting actions have been reported. However, there is no clear experimental or epidemiological evidence for a direct carcinogenic action of zinc or its compounds.


Justification for selection of carcinogenicity via oral route endpoint:
A weight of evidence approach has been adopted for this endpoint therefore it was not possible to select only one study.

Justification for selection of carcinogenicity via inhalation route endpoint:
A weight of evidence approach has been adopted for this endpoint therefore it was not possible to select only one study.

Justification for classification or non-classification

Zinc compounds and methyl methacrylate are considered to have no carcinogenic potential therefore zinc methacrylate does not need to be classified for carcinogenicity under the Dangerous Substance Directive 67/548/EEC or Regulation (EC) 1272-2008.