Registration Dossier
Registration Dossier
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EC number: 254-414-3 | CAS number: 39322-78-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Phosphoric acid, 2-ethylhexyl ester was administered to rats by stomach tube at a dose of 200 mg/kg bw . After application urine and feces was collected every 12 h for a total of 72 h.Samples were analysed via P31-NMR spectroscopy.Sodium hydroxide was added to 700 µL urine sample to reach a pH of 9. Thereafter, the samples were mixed with 200 µL D2O and measured. Only Phosphate peak was found in the urine samples. Therefore, it was concluded, that Phosphoric acid, 2-ethylhexyl ester is quantitatively hydrolysed to Phosphate and the alcoholic compound, 2-Ethylhexanol.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Phosphoric acid, 2 -ethylhexyl ester (the test item used in this metabolism/excretion study) and Phosphoric acid, dodecyl ester potaassium salt (the substance to be registered) are member of the Phosphoric acid, alcyl ester family.The characteristic and functional active center of both substances is the ester binding between the alcoholic compoound and Phosphate. With reference to the occurrence of esterases which take part in the mammalian phase I metabolism it can be assumed that both Phosphoric acid esters are hydrolysed independent from the constitution of the alcoholic part. Since the ester binding is the specific target of endogenous esterases it is justified to perform a read across between the both ester type substances Phosphoric acid, 2 -ethylhexyl ester and Phosphoric acid, dodecyl ester potassium salt in order to estimate its potential metabolism.
5 male and 5 female rats received 200 mg/kg bw Phosphoric acid, 2 -ethylhexyl ester via gavage. Urine and feces were collected in 12 h intervals for 72 h. The samples were analysed by NMR spectroscopy.
Besides the Phosphate peak no other peaks were detected indicating a complete hydrolysis of the Phosphoric acid ester into Phosphate and 2 -Ethylhexanol.
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