Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-274-3 | CAS number: 56-45-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Regarding reproductive toxicity/fertility no study reports for L-serine are available.
A significant amount of L-serine is usually taken up via the food. In usual diet, most amino acids are supplied as constituents of protein and not as free amino acid. Food consumption data indicate that 7.2 g L-serine is consumed daily with a daily intake of 100 g protein. Protein intake clearly modifies plasma amino acid levels. However, amino acid concentrations are subject to homeostasis and the plasma concentrations vary within fixed limits and are tightly regulated.
Exposure with L-serine from uses which are covered by this registration would only marginally increase the total daily L-serine dose which is taken up via the food. Even if the plasma amino acid concentration would increase/vary by any use such fluctuations are physiological and subject to homeostasis. Therefore it is highly unlikely that L-serine taken up via any use covered by this registration would result in systemic effects.
Several repeated dose toxicity studies consistently indicate the very low toxicity of L-serine. Even in very high doses no toxicity is observed and no adverse effects were reported for the reproductive organs.
Short description of key information:
No evidence for effects on fertility.
Effects on developmental toxicity
Description of key information
No evidence for developmental toxicity.
Additional information
Regarding developmental toxicity/teratogenicity no study reports for L-serine are available.
A significant amount of L-serine is usually taken up via the food. In usual diet, most amino acids are supplied as constituents of protein and not as free amino acid. Food consumption data indicate that 7.2 g L-serine is consumed daily with a daily intake of 100 g protein. Protein intake clearly modifies plasma amino acid levels. However, amino acid concentrations are subject to homeostasis and the plasma concentrations vary within fixed limits and are tightly regulated.
Exposure with L-serine from uses which are covered by this registration would only marginally increase the total daily L-serine dose which is taken up via the food. Even if the plasma amino acid concentration would increase/vary by any use such fluctuations are physiological and subject to homeostasis. Therefore it is highly unlikely that L-serine taken up via any use covered by this registration would result in systemic effects.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
