Registration Dossier
Registration Dossier
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EC number: 244-491-1 | CAS number: 21643-42-5
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-Propenoic acid, C12-14-alkyl esters
- EC Number:
- 282-516-8
- EC Name:
- 2-Propenoic acid, C12-14-alkyl esters
- Cas Number:
- 84238-60-8
- Molecular formula:
- Unspecified
- IUPAC Name:
- 2-Propenoic acid, C12-14-alkyl esters
- Test material form:
- other: Liquid
Constituent 1
- Radiolabelling:
- no
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- As the amount of the acrylate (2-Propenoic acid, C12-14-alkyl esters) decreases, the amount of acrylic acid increases in correlation.
Any other information on results incl. tables
Incubation in rat liver S9 mix
The hydrolysis of 2 -Propenoic acid, C12 -14 -alkyl esters shows that the hydrolysis rate of 2 -Propenoic acid, C12 -alkyl ester is in parallel with but a little bit faster than that of 2 -Propenoic acid, C14 -alkyl ester. The amount of acrylic acid increased in correlation with the decrease of 2 -Propenoic acid, C12 -14 -alkyl esters.
Incubation in rat plasma
After 120 minutes a reduction of 2 -Propenoic acid, C12 -14 -alkyl esters of almost 100 % is observed. At the same time the acrylic acid increased by 50 %.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
