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Environmental fate & pathways

Biodegradation in water and sediment: simulation tests

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Administrative data

Endpoint:
biodegradation in water: simulation testing on ultimate degradation in surface water
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
Please refer to the attached QMRF and QPRF

Data source

Referenceopen allclose all

Reference Type:
other: QSAR Method Reporting Format
Title:
Unnamed
Year:
2019
Report date:
2019
Reference Type:
other: QSAR Prediction Reporting Format
Title:
Unnamed
Year:
2021
Report date:
2021
Reference Type:
other: QSAR
Title:
EpiSuite v4.11, BioHCwin v1.01
Author:
Howard et al.
Year:
2010
Bibliographic source:
Howard, P.H., W.M., Meylan, Aronson, D., Stiteler,W.M., Tunkel, J., Comber, M. and Parkerton, F.  2005.  A New Biodegradation Prediction Model Specific to Petroleum Hydrocarbons. Environ. Toxicol. Chem. 24(8): 1847-1860

Materials and methods

Test guideline
Guideline:
other: Reach Guidance on QSARs R.6
Principles of method if other than guideline:
The result was obtained using an appropriate QSAR method (see attached QMRF and QPRF for details).

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydrocarbons, C18-C24, iso-alkanes <2% aromatics
EC Number:
940-734-7
Molecular formula:
C18H38, C19H40, C20H42, C21H44, C22H46, C23H48, C24H50
IUPAC Name:
Hydrocarbons, C18-C24, iso-alkanes <2% aromatics

Results and discussion

Half-life of parent compound / 50% disappearance time (DT50)
Compartment:
water
DT50:
>= 29 d

Applicant's summary and conclusion

Conclusions:
C8-26 branched and linear alkanes are predicted to have biodegradation half-life in water of ≤294 days. The results are considered to be reliable.