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Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

See also attached safety data sheet

INHALATION
Move the exposed person to fresh air at once. Get medical attention.

INGESTION
Toxic if swallowed. Wash out mouth with water, provided person is conscious. Get medical attention immediately.

SKIN CONTACT
May cause an allergic skin reaction.
Remove contaminated clothing and wash skin with soap and plenty of running water. Get medical attention.

EYE CONTACT
Causes serious eye damage. Rinse immediately eye with plenty of low pressure water for at least 15 minutes.
Remove any contact lenses. Get medical attention.

Fire-fighting measures

See also attached safety data sheet

EEXTINGUISHING MEDIA, FLASHPOINT, AUTOIGNITION
Flashpoint 150 °C (closed cup)
Autoignition temperature 500 °C
To extinguish fire use water spray, dry powder, carbon dioxide, or foam.

FLAMMABILITY, EXPLOSIVENESS, OXIDISING PROPERTIES
The substance is not flammable, not explosive, but has oxidizing properties

SPECIAL FIRE FIGHTING PROCEDURES
Prevent run-off water from entering the sewer system.

UNUSUAL FIRE & EXPLOSION HAZARDS
None.

SPECIFIC HAZARDS
By fire toxic gases may be formed (Cox).

PROTECTIVE MEASURES IN FIRE
Self contained breathing apparatus and full protective clothing.

Accidental release measures

See also attached safety data sheet

PERSONAL PRECAUTIONS
See section on exposure controls / personal protection

ENVIRONMENTAL PRECAUTIONS
Take precautionary measures against discharges into the environment.

SPILL CLEAN UP METHODS
Collect spilled material without creating dust, then place into a suitable closed container for disposal as chemical waste.

Handling and storage

See also attached safety data sheet

USAGE PRECAUTIONS
Avoid contact with eyes or skin.
Wash thoroughly after handling and before eating, drinking or smoking.

STORAGE PRECAUTIONS
To protect product quality, store in sealed container in a cool place and out of direct sunlight.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:
UN number 2811 (toxic solid, organic, N.O.S.)
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Marine transport (UN RTDG/IMDG)

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Exposure controls / personal protection

EXPOSURE LIMITS
None listed.

USE LIMITS
The substance is used as a precursor for oxidative hair colours and as an ingredient in oxidation dye formulations as well as in dyeing formulations without a hydrogen peroxide based developer mix, with a final maximum on head concentration of 1.8%.

PNECs:
aqua-freshwater: 0.249 mg/L
aqua-marine water: 0.0249 mg/L
sewage treatment plant: 0.32 mg/L
sediment-freshwater: 4.28 mg /kg dw
sediment-marine water: 0.428 mg /kg dw
soil: 0.709 mg /kg dw

DNELs:
The main derived long-term DNELs for systemic effects are:
Workers General population
Oral not relevant 0.50 mg/kg bw/day
Dermal 1.4 mg/kg bw/day 0.50 mg/kg bw/day
Inhalation 4.93 mg/m3 0.87 mg/m3

INDUSTRIAL WORKERS TOXICITY

The CHESAR Tool version 3.3.0, exposure model for this substance shows for
• indoor industrial activities
• with an advanced occupational health and safety system
• taking more than 4 hours/day
• with local exhaust ventilation (LEV) present (and running)
• provided workers wear gloves with at least 80% dermal protection

the following long term systemic exposures:

Inhalation (mg/m3) dermal (mg/kg/day) RCR (inh) RCR (dermal) RCR (total)
PROC1 0.007 0.007 < 0.01 < 0.01 < 0.01
Use in closed process, no likelihood of exposure
PROC2 0.0007 0.274 < 0.01 0.196 0.196
Use in closed, continuous process with occasional controlled exposure
PROC3 0.007 0.138 < 0.01 0.099 0.100
Use in closed batch process (synthesis or formulation)
PROC4 0.035 1.372 < 0.01 0.98 0.987
Use in batch and other process (synthesis) where opportunity for exposure arises
PROC5 0.035 1.371 < 0.01 0.979 0.986
Mixing or blending in batch processes for formulation of preparations and articles (multistage and/or significant contact)
PROC8a 0.035 1.371 < 0.01 0.979 0.986
Transfer of substance or preparation (charg-ing/discharging) from/to vessels/large containers at non-dedicated facilities
PROC8b 0.003 1.371 < 0.01 0.979 0.98
Transfer of chemicals from/to vessels/large containers at dedicated facilities
PROC9 0.007 0.686 < 0.01 0.49 0.491
Transfer of chemicals into small containers (dedicated filling line)
PROC15 0.007 0.034 < 0.01 0.024 0.026
Use of laboratory reagents in small scale laboratories

Notes:
• Good general ventilation is assumed in all cases (3-5 air exchanges per hour)
• Dustiness of the substance was set at “low”
• LEV is considered only for inhalation exposures and its efficiencies are as follows:
o For PROC1 LEV is not an exposure modifier
o For PROC8b LEV reduces inhalation exposure with 95%
o For all other PROCs LEV reduces inhalation exposure with 90%
• The applied RMMs/OCs will also control the risks relating to possible skin & eye irritation and skin sensitisation

The RMMs/OCs for the use of 2-methylresorcinol in an industrial environment:
• Indoor industrial activities taking more than 4 hours per day
• With an advanced occupational health and safety system
• Local Exhaust Ventilation (LEV) and good general ventilation (3-5 air changes per hour)
• Gloves with at least 80% dermal protection: Use chemical resistant gloves classified under Standard EN374, class 6 (breakthrough time > 480 minutes)
• Wear approved safety goggles for eye protection
• Low dustiness of the substance

CONSUMER TOXICITY

To cover PC39 (cosmetics & personal care products) the consumer exposure scenario was calculated with CHESAR v 3.0.0. The parameters were: percentage of substance in mixture <=3.0%; liquid product; only exposure via the dermal route; frequent annual use/once per day; adults assumed; exposure to the inside of both hands; dermal transfer factor = 0.2

The result was a total dermal systemic dose of 0.429 mg/kg/day, or an RCR of 0.858

Note: the maximum concentration of 2-methylresorcinol allowed on-head is 3.0% under the assumption that the uptake of this substance through the skin is not more than 20% (maximum experimental value found: 20 %)

MAXIMUM CONCENTRATION OF SUBSTANCE IN A MIXTURE
In a consumer environment the substance is only to be used in a mixture with a maximum on-head concentration of 3.0 %.

PROTECTIVE EQUIPMENT
Protective gloves, safety goggles, and protective clothing.

RESPIRATORY EQUIPMENT
None


HAND PROTECTION
Protective gloves: Use chemical resistant gloves classified under Standard EN374, class 6 (breakthrough time > 480 minutes).

EYE PROTECTION
Wear approved safety goggles.

HYGIENE MEASURES
Wash at the end of each work shift and before eating, drinking, smoking or using the toilet.

SKIN PROTECTION
Wear protective clothing.

Stability and reactivity

See also attached safety data sheet

STABILITY
Stable under normal temperature conditions and recommended use.

MATERIALS TO AVOID
Strong oxidising agents, strong acids, strong bases

HAZARDOUS DECOMPOSITION PRODUCTS
By fire toxic gases (COx) may be formed

Disposal considerations

See also attached safety data sheet

GENERAL INFORMATION
Place into a suitable closed container for disposal as chemical waste.

DISPOSAL METHODS
Dispose of in accordance with local and national regulations.