3-mercaptopropionic acid

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

not reported

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: non-GLP, but similar to guideline study.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Deviations:

yes

Remarks:

non-GLP study

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-mercaptopropionic acid

EC Number:

203-537-0

EC Name:

3-mercaptopropionic acid

Cas Number:

107-96-0

Molecular formula:

C3H6O2S

IUPAC Name:

3-sulfanylpropanoic acid

Test material form:

solid - liquid: suspension

Details on test material:

no data

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Details on test animals or tissues and environmental conditions:

no data

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not required

Amount / concentration applied:

undiluted
Amount applied: 0.1 g

Duration of treatment / exposure:

30 sec / unlimited

Observation period (in vivo):

14 d

Number of animals or in vitro replicates:

1

Details on study design:

REMOVAL OF TEST SUBSTANCE
- Washing (if done): one eye was rinsed after 30 sec, the other treated eye was not rinsed
- Time after start of exposure: 30 sec


SCORING SYSTEM: no data


TOOL USED TO ASSESS SCORE: fuorescein

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

other: corneal injury

Basis:

animal #1

Remarks:

severe

Reversibility:

not reversible

Remarks on result:

other: only qualitative description of the effects

Results 2

Irritation parameter:

other: conjunctival inflammation

Basis:

animal #1

Remarks:

severe

Reversibility:

not reversible

Remarks on result:

other: only qualitative description of the effects

Irritant / corrosive response data:

Instillation of 3-MPA into a rabbit's eyes resulted in severe pain, severe corneal injury and severe conjunctival inflammation.  These effects were noted immediately after instillation and persisted through 14 days of observation.  The response of the washed eye was the same as that in the eye which was not washed.  This indicates the damage to the cornea was permanent.

Applicant's summary and conclusion

Interpretation of results:

Category 1 (irreversible effects on the eye) based on GHS criteria

Conclusions:

3-MPA is corrosive and causes serious eye damage.