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EC number: 206-056-4 | CAS number: 298-07-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: special investigation
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Induction of cytosolic and microsomal epoxide hydrolases in murine liver by known peroxisome proliferators and structurally related substances
- Author:
- Lundgren B, Meijer J, DePierre JW
- Year:
- 1 988
- Bibliographic source:
- Arch Toxicol Suppl 12, 288-293 (1988)
- Reference Type:
- publication
- Title:
- induction of xenobiotic-metabolizing enzymes and peroxisome proliferation in rat liver caused by dietary exposure to di(2-ethylhexyl)phosphate
- Author:
- Lundgren B, DePierre JW
- Year:
- 1 987
- Bibliographic source:
- Xenobiotica 17, 5, 585-593 (1987)
- Reference Type:
- publication
- Title:
- Induction of cytosolic and microsomal epoxide hydrolases in mouse liver by peroxisome proliferators with special emphasis on structural analogues of 2-ethylhexanoic acid
- Author:
- Lundgren B, Meijer J, Birberg W, Pilotti A, DePierre JW
- Year:
- 1 988
- Bibliographic source:
- Chem-Biol Interactions 68, 219-240 (1988)
- Reference Type:
- publication
- Title:
- Hepatic peroxisome proliferation in rodents and its significance for humans
- Author:
- Bentley P, Calder I, Elcombe C, Grass P, Stringer D, Wiegand H
- Year:
- 1 993
- Bibliographic source:
- Fd Chem Toxic, 31, 857-907 (1993)
Materials and methods
- Type of study / information:
- Induction of xenobiotic-metabolizing enzymes by bis(2-ethylhexyl) hydrogen phosphate
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The hepatic cytosolic epoxide hydrolase activity was determined after application of the test substances (e.g. bis(2-ethylhexyl) hydrogen phosphate) to rats or mice.
- GLP compliance:
- no
Test material
- Reference substance name:
- Bis(2-ethylhexyl) hydrogen phosphate
- EC Number:
- 206-056-4
- EC Name:
- Bis(2-ethylhexyl) hydrogen phosphate
- Cas Number:
- 298-07-7
- Molecular formula:
- C16H35O4P
- IUPAC Name:
- bis(2-ethylhexyl) hydrogen phosphate
Constituent 1
Results and discussion
Any other information on results incl. tables
An induction of liver enzyme activity (peroxisome proliferation, induction of epoxid hydrolase) was found after application of bis(2-ethylhexyl) hydrogen phosphate.
Applicant's summary and conclusion
- Executive summary:
Bis(2-ethylhexyl) hydrogen phosphate were applied by diet for several days to rats or mice and epoxide hydrolase activities were measured using established procedures.
An induction of liver enzyme activity (peroxisome proliferation, induction of epoxid hydrolase) was found after application of bis(2-ethylhexyl) hydrogen phosphate.
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