Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 206-056-4 | CAS number: 298-07-7
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: special investigation
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Induction of cytosolic and microsomal epoxide hydrolases in murine liver by known peroxisome proliferators and structurally related substances
- Author:
- Lundgren B, Meijer J, DePierre JW
- Year:
- 1 988
- Bibliographic source:
- Arch Toxicol Suppl 12, 288-293 (1988)
- Reference Type:
- publication
- Title:
- induction of xenobiotic-metabolizing enzymes and peroxisome proliferation in rat liver caused by dietary exposure to di(2-ethylhexyl)phosphate
- Author:
- Lundgren B, DePierre JW
- Year:
- 1 987
- Bibliographic source:
- Xenobiotica 17, 5, 585-593 (1987)
- Reference Type:
- publication
- Title:
- Induction of cytosolic and microsomal epoxide hydrolases in mouse liver by peroxisome proliferators with special emphasis on structural analogues of 2-ethylhexanoic acid
- Author:
- Lundgren B, Meijer J, Birberg W, Pilotti A, DePierre JW
- Year:
- 1 988
- Bibliographic source:
- Chem-Biol Interactions 68, 219-240 (1988)
- Reference Type:
- publication
- Title:
- Hepatic peroxisome proliferation in rodents and its significance for humans
- Author:
- Bentley P, Calder I, Elcombe C, Grass P, Stringer D, Wiegand H
- Year:
- 1 993
- Bibliographic source:
- Fd Chem Toxic, 31, 857-907 (1993)
Materials and methods
- Type of study / information:
- Induction of xenobiotic-metabolizing enzymes by bis(2-ethylhexyl) hydrogen phosphate
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The hepatic cytosolic epoxide hydrolase activity was determined after application of the test substances (e.g. bis(2-ethylhexyl) hydrogen phosphate) to rats or mice.
- GLP compliance:
- no
Test material
- Reference substance name:
- Bis(2-ethylhexyl) hydrogen phosphate
- EC Number:
- 206-056-4
- EC Name:
- Bis(2-ethylhexyl) hydrogen phosphate
- Cas Number:
- 298-07-7
- Molecular formula:
- C16H35O4P
- IUPAC Name:
- bis(2-ethylhexyl) hydrogen phosphate
Constituent 1
Results and discussion
Any other information on results incl. tables
An induction of liver enzyme activity (peroxisome proliferation, induction of epoxid hydrolase) was found after application of bis(2-ethylhexyl) hydrogen phosphate.
Applicant's summary and conclusion
- Executive summary:
Bis(2-ethylhexyl) hydrogen phosphate were applied by diet for several days to rats or mice and epoxide hydrolase activities were measured using established procedures.
An induction of liver enzyme activity (peroxisome proliferation, induction of epoxid hydrolase) was found after application of bis(2-ethylhexyl) hydrogen phosphate.
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