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EC number: 206-056-4 | CAS number: 298-07-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There are no toxicokinetic studies available for bis(2-ethylhexyl) hydrogen phosphate. Analoguous to other esters of phosphoric acid initially a hydrolysis to the monoester (2-ethylhexyl dihydrogen phosphate (CAS No. 1070-03-7)) can be anticipated (BUA Report 172, ISBN 3-7776-0704-5).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Bis(2-ethylhexyl) hydrogen phosphate has a low water solubility (solubility 0.182 g/L) and an estimated log Kow of 6.07. Therefore a low bioaccumulation potential is expected.
Rats were exposed for 5 days to bis(2-ethylhexyl) hydrogen phosphate in diet and the induction of liver enzymes was evaluated.
Dietary exposure to bis(2-ethylhexyl) hydrogen phosphate results in a relatively large increases in the microsomal content of cytochrome P-450 and cytosolic epoxide hydrolase activity in rat liver. The authors of the study postulated that the metabolite 2-ethylhexanol is responsible for the induction of xenobiotic-metabolising enzymes and/or the proliferation of peroxisomes and/or mitochondria.
Analoguous to other esters of phosphoric acid initially a hydrolysis to the monoester can be anticipated. 2-Ethylhexan-1-ol (CAS No. 104-76-7) and the 2-ethylhexyl dihydrogen phosphate (CAS No. 1070-03-7) can be expected as metabolites.
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