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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

There are no toxicokinetic studies available for bis(2-ethylhexyl) hydrogen phosphate. Analoguous to other esters of phosphoric acid initially a hydrolysis to the monoester (2-ethylhexyl dihydrogen phosphate (CAS No. 1070-03-7)) can be anticipated (BUA Report 172, ISBN 3-7776-0704-5).

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

Bis(2-ethylhexyl) hydrogen phosphate has a low water solubility (solubility 0.182 g/L) and an estimated log Kow of 6.07. Therefore a low bioaccumulation potential is expected.

Rats were exposed for 5 days to bis(2-ethylhexyl) hydrogen phosphate in diet and the induction of liver enzymes was evaluated.

Dietary exposure to bis(2-ethylhexyl) hydrogen phosphate results in a relatively large increases in the microsomal content of cytochrome P-450 and cytosolic epoxide hydrolase activity in rat liver. The authors of the study postulated that the metabolite 2-ethylhexanol is responsible for the induction of xenobiotic-metabolising enzymes and/or the proliferation of peroxisomes and/or mitochondria.

Analoguous to other esters of phosphoric acid initially a hydrolysis to the monoester can be anticipated. 2-Ethylhexan-1-ol (CAS No. 104-76-7) and the 2-ethylhexyl dihydrogen phosphate (CAS No. 1070-03-7) can be expected as metabolites.