Registration Dossier
Registration Dossier
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EC number: 206-056-4 | CAS number: 298-07-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There are no toxicokinetic studies available for bis(2-ethylhexyl) hydrogen phosphate. Analoguous to other esters of phosphoric acid initially a hydrolysis to the monoester (2-ethylhexyl dihydrogen phosphate (CAS No. 1070-03-7)) can be anticipated (BUA Report 172, ISBN 3-7776-0704-5).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Bis(2-ethylhexyl) hydrogen phosphate has a low water solubility (solubility 0.182 g/L) and an estimated log Kow of 6.07. Therefore a low bioaccumulation potential is expected.
Rats were exposed for 5 days to bis(2-ethylhexyl) hydrogen phosphate in diet and the induction of liver enzymes was evaluated.
Dietary exposure to bis(2-ethylhexyl) hydrogen phosphate results in a relatively large increases in the microsomal content of cytochrome P-450 and cytosolic epoxide hydrolase activity in rat liver. The authors of the study postulated that the metabolite 2-ethylhexanol is responsible for the induction of xenobiotic-metabolising enzymes and/or the proliferation of peroxisomes and/or mitochondria.
Analoguous to other esters of phosphoric acid initially a hydrolysis to the monoester can be anticipated. 2-Ethylhexan-1-ol (CAS No. 104-76-7) and the 2-ethylhexyl dihydrogen phosphate (CAS No. 1070-03-7) can be expected as metabolites.
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